{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:15:53Z","timestamp":1778199353287,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While clinical surveys have frequently reported that patients with traumatic brain injuries (TBIs) and comorbidities experience faster healing, the underlying mechanisms have been investigated but remain unclear. As a comprehensive comparison and analysis of the metabolic characteristics of these two pathologies have not been undertaken, we developed a rat model of fracture and TBI and collected serum samples for metabolomic analysis using ultra\u2010high performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight MS (UHPLC\u2013Q\u2010TOF\/MS). In total, we identified 40 differential metabolites and uncovered related pathways and potential mechanisms, including aminoacyl\u2010transfer RNA biosynthesis; differential amino acids such as leucine, cholylhistidine, aspartyl\u2010lysine; and related lipid metabolism, and discussed their impacts on bone formation in detail. This study highlights that the UHPLC\u2013Q\u2010TOF\/MS\u2013based metabolomics approach offers a better understanding of the metabolic links between TBI and accelerated bone recovery.<\/jats:p>","DOI":"10.1002\/bmc.5733","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:55:55Z","timestamp":1694649355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolomics provides insights into acceleration of bone healing in fractured patients with traumatic brain injuries"],"prefix":"10.1002","volume":"37","author":[{"given":"Demeng","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Pharmacy Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xue","sequence":"additional","affiliation":[{"name":"Cinical Research Unit, Changhai Hospital Naval Military University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gehan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-7856","authenticated-orcid":false,"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital Naval Military University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11090628"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0641959"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac800795f"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01303-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(17)30222-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00520"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10380"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2023.116681"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12153"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.164"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2015.02.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198808000-00011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00205-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10360"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/204842"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.08.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101203"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010089"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-199809000-00005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.12.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.241497"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3652"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672-7347.2017.02.006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab492"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-021-00602-y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2022.09.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1332180"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2004.08.028"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157908"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082449"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8835730"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17026-6"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.56"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.011"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27927"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01615-5"},{"issue":"1","key":"e_1_2_10_38_1","first-page":"7","article-title":"Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture","volume":"14","author":"Wang L.","year":"2011","journal-title":"Chinese Journal of Traumatology"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2442"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0158"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123265119"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.7507\/1002-1892.201612048"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4240"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201901242"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20576"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18171-8"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.5733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:00:49Z","timestamp":1760043649000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.5733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/bmc.5733"],"URL":"https:\/\/doi.org\/10.1002\/bmc.5733","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5733"}}