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At present, there is no report regarding the drug metabolism of BJG <jats:italic>in vivo<\/jats:italic>. This work developed an ultra\u2010high\u2010performance liquid chromatography coupled with triple quadrupole mass spectrometry method with high accuracy and sensitivity to determine drug metabolism of this compound <jats:italic>in vivo<\/jats:italic>. After continuous administration of BJG, the concentrations of 10 components in rat plasma, namely betaine, peimine, peiminine, astragaloside A, sinensetin, nobiletin, naringin, calycosin, formononetin, and magnolol, were determined at different time points. Meanwhile, the pharmacokinetic parameters and metabolic rules of these 10 components were evaluated: <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>, 8.624\u2013574.645\u2009ng\/mL; <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>, 0.250\u20138.667\u2009h; AUC<jats:sub>0\u2013<jats:italic>t<\/jats:italic><\/jats:sub>, 17.640\u20138947.393\u2009ng\u2009h\/mL; <jats:italic>T<\/jats:italic><jats:sub>1\/2<\/jats:sub>, 3.405\u201366.014\u2009h; mean residence time (MRT), 6.893\u201311.223\u2009h. All these components possessed anti\u2010inflammatory, antioxidant, and other biological activities to varying degrees, contributing to improving lung function, mitigating pneumonia and pulmonary fibrosis, and preventing and treating chronic obstructive pulmonary disease. Exploring the pharmacokinetic parameters and the laws of chemical components in BJG forms the scientific basis for applying the compound clinically and identifying quality markers for the control of the compound.<\/jats:p>","DOI":"10.1002\/bmc.5740","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:36:57Z","timestamp":1693967817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic regularity of bioactive compounds in Bufei Jianpi granule in rats using ultra\u2010high\u2010performance liquid chromatography coupled with triple quadrupole mass spectrometry analysis technology"],"prefix":"10.1002","volume":"37","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian China"},{"name":"Liaoning Multi\u2010dimensional Analysis of Traditional Chinese Medicine Technical 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