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However, the mechanisms of AB23A on NASH remain unclear. This study aimed to investigate the mechanisms underlying the metabolic regulatory effects of AB23A on NASH. We used AB23A to treat mice with NASH, which was induced by a methionine and choline deficient (MCD) diet. We initially investigated therapeutic effect and resistance to oxidation and inflammation of AB23A on NASH. Subsequently, we performed untargeted metabolomic analyses and relative validation assessments to evaluate the metabolic regulatory effects of AB23A. AB23A reduced lipid accumulation, ameliorated oxidative stress and decreased pro\u2010inflammatory cytokines in the liver. Untargeted metabolomic analysis found that AB23A altered the metabolites of liver. A total of 55 differential metabolites and three common changed pathways were screened among the control, model and AB23A treatment groups. Further tests validated the effects of AB23A on modulating common changed pathway\u2010involved factors. AB23A treatment can ameliorate NASH by inhibiting oxidative stress and inflammation. The mechanism of AB23A on NASH may be related to the regulation of alanine, aspartate and glutamate metabolism, <jats:sc>d<\/jats:sc>\u2010glutamine and <jats:sc>d<\/jats:sc>\u2010glutamate metabolism, and arginine biosynthesis pathways.<\/jats:p>","DOI":"10.1002\/bmc.5763","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:50:51Z","timestamp":1697763051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mechanical study of alisol B 23\u2010acetate on methionine and choline deficient diet\u2010induced nonalcoholic steatohepatitis based on untargeted metabolomics"],"prefix":"10.1002","volume":"38","author":[{"given":"Hua\u2010jun","family":"Li","sequence":"first","affiliation":[{"name":"Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine  Cangzhou 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