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In this research, we developed and validated rapid, sensitive, and selective ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2013MS\/MS) methods for quantifying GL\u2010V9 and 5\u2010O\u2010glucuronide GL\u2010V9 in various biological samples, including SD rat plasma, tissue homogenate, bile, urine, and feces. Quantification of GL\u2010V9 and 5\u2010O\u2010glucuronide GL\u2010V9 in plasma, tissue homogenate, bile, urine, and feces was performed using the validated LC\u2013MS\/MS methods. The bioavailability of GL\u2010V9 in SD rats ranged from 6.23% to 7.08%, and both GL\u2010V9 and 5\u2010O\u2010glucuronide GL\u2010V9 exhibited wide distribution and rapid elimination from tissues. The primary distribution tissues for GL\u2010V9 and 5\u2010O\u2010glucuronide GL\u2010V9 in rats were the duodenum, liver, and lung. GL\u2010V9 was predominantly excreted in urine, while 5\u2010O\u2010glucuronide GL\u2010V9 was primarily excreted in bile. GL\u2010V9 exhibited easy absorption and rapid conversion to its glucuronide metabolite, 5\u2010O\u2010glucuronide GL\u2010V9, following administration.<\/jats:p>","DOI":"10.1002\/bmc.5828","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:18:53Z","timestamp":1707283133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics, tissue distribution, and excretion study of GL\u2010V9 and its glucuronide metabolite 5\u2010O\u2010glucuronide GL\u2010V9 in Sprague\u2013Dawley rats"],"prefix":"10.1002","volume":"38","author":[{"given":"Xuefeng","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University  Nanjing People\u2019s Republic of China"},{"name":"TriApex 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