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In this study, we found that olanzapine\u2010treated mice showed varying degrees of dyslipidemia, which was particularly pronounced in female mice. Based on ultra\u2010performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight\u2013MS (UPLC\u2013Q\u2010TOF\u2013MS) technology and lipid metabolomics, we mapped the changes in lipid metabolism in olanzapine\u2010treated mice and then compared the changes in lipid metabolism between male and female mice. There were 98 metabolic differentiators between the olanzapine\u2010treated and control groups in females and 79 in males. These metabolites were glycerolipids, glycerophospholipids, fatty amides, and sphingolipids, which are involved in glycerolipid metabolism, glycerophospholipid metabolism, and fatty acid metabolism. These results suggest that olanzapine\u2010induced changes in the levels of lipid metabolites are closely associated with disturbances in lipid metabolic pathways, which may underlie lipemia. This lipidome profiling study not only visualizes changes in lipid metabolism in liver tissue but also provides a foundation for understanding the regulatory pathways and mechanisms involved in olanzapine\u2010induced lipid metabolism disorders. 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