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While previous studies have primarily focused on genomics and genetics in osteoporosis susceptibility, there is a lack of systematic exploration of sex\u2010specific differences in lipid levels in mouse bone marrow. Multiple reaction monitoring\u2010based liquid chromatography\u2013trandem mass spectrometry\u00a0(LC\u2013MS\/MS) was used to quantify lipidomic profiles in bone marrow samples from three female mice and three male mice. The LC\u2013MS\/MS technique based on the multiple reaction monitoring method identified and quantified 184 lipids from 15 lipid classes. The contents of most lipids in the bone marrow cells of female mice were higher than those in male mice, including four polyunsaturated fatty acids, three phospholipids and four sphingolipids. Among all the lipid molecules, lactosylceramide (d18:0\/16:0) showed the highest fold change in female mice, while its precursor lipid, glucosylceramide, was the most up\u2010regulated in male mice. This study, focusing on bone marrow lipidomics, elucidates significant sexual dimorphism in lipid levels within bone marrow cells. It provides novel evidence supporting the higher prevalence of osteoporosis in women and enhances our understanding of the connection between sex\u2010specific lipid levels and the risk of osteoporosis.<\/jats:p>","DOI":"10.1002\/bmc.5875","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T19:58:31Z","timestamp":1713729511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The bone marrow lipidomics of mice reveal sex\u2010related differences"],"prefix":"10.1002","volume":"38","author":[{"given":"Ziqing","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The Second Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojian","family":"Hu","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 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