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In this study, the material basis and mechanism of ZP in the treatment of fundus lesions were evaluated via the high\u2010performance liquid chromatography fingerprint, ultra\u2010performance liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry, network pharmacology and molecular docking. A total of 32 common components were found and 31 components were identified in 15 batches of ZP samples. Moreover, 134 common key targets and 17 putative active components that are connected to fundus lesions were identified. Molecular docking revealed that quercetin, kaempferol, isorhamnetin, 5\u2010<jats:italic>O<\/jats:italic>\u2010feruloylquinic acid, plantagoside and 2\u2032\u2010acetylacteoside have the ability to interact with the core targets such as AKT1, TP53, TNF, IL\u20106 and Jun. Our findings revealed that the therapeutic effects of ZP on fundus lesions are mediated by multiple components, targets and pathways, including at least six active ingredients and 11 targets. The study provides new ideas for further research on the material basis and mechanisms of traditional Chinese medicine prescriptions.<\/jats:p>","DOI":"10.1002\/bmc.5885","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:00:01Z","timestamp":1715565601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study on the material basis of Zhujing pill in treating fundus lesions through component analysis and network pharmacology"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1198-6680","authenticated-orcid":false,"given":"Yijie","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202001093"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98925-6"},{"issue":"98","key":"e_1_2_10_4_1","first-page":"164","article-title":"The clinical effective rate of modified Zhujing pills prescription in the treatment of primary retinitis pigmentosa and its effect on visual acuity of patients","volume":"5","author":"Fan M. 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