{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:09:39Z","timestamp":1785845379892,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009392","name":"K L University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study describes the development of a reliable and linear analytical method for precisely determining dimethylamine impurity in <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylformamide solvent utilizing a benzoyl chloride derivatization reagent and a gas chromatography mass spectrometer. Benzoyl chloride was used to derivatize dimethylamine. At normal temperature, benzoyl chloride combined with dimethylamine, producing <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide. This method separated <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide using Rtx\u20105 amine (30\u2009m\u2009\u00d7\u20090.32\u2009mm\u2009\u00d7\u20091.50\u2009\u03bcm) as the stationary phase, helium as the carrier gas, argon as the collision gas, and methanol as the diluent. The column flow rate was 2\u00a0mL\/min. The retention time of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide was determined to be 8.5\u00a0min. Precision, linearity, and accuracy were tested using ICH Q2 (R2) and USP&lt;1225&gt; guidelines. The percentage coefficient of variation (CV) for <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide in the system suitability parameter was 1.1%. The correlation coefficient of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide was found to be &gt;0.99. In the method precision parameter, the % CV for <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide was found to be 1.9%, whereas the % CV for <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide was 1.2% in intermediate precision. The percentage recovery of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylbenzamide was determined to be between 80% and 98%.<\/jats:p>","DOI":"10.1002\/bmc.5920","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T22:54:28Z","timestamp":1717714468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gas chromatography mass spectrometer determination of dimethylamine impurity in <i>N<\/i>,<i>N<\/i>\u2010dimethylformamide solvent by derivatization of <i>N<\/i>,<i>N<\/i>\u2010dimethylbenzamide with benzoyl chloride agent"],"prefix":"10.1002","volume":"38","author":[{"given":"Sayyad","family":"Kousrali","sequence":"first","affiliation":[{"name":"Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leela Prasad","family":"Kowtharapu","sequence":"additional","affiliation":[{"name":"Analytical Development Department Shenzhen DEC Pharmaceutical Co., Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-795X","authenticated-orcid":false,"given":"Tanmoy","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"65","article-title":"A sensitive, stability indicating UPLC method for the identification and characterization of forced degradation products for drometrizole trisiloxane through MSn studies","volume":"8","author":"Ajay Babu M.","year":"2018","journal-title":"Journal of Applied Pharmaceutical Sciences"},{"key":"e_1_2_7_3_1","volume-title":"Advantages of 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