{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:58:16Z","timestamp":1761429496406,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chuanwang Xiaoyan (CWXY) capsule is primarily used to treat a variety of acute and chronic inflammations, including acute and chronic pharyngitis and tonsillitis. However, a systematic study of its chemical constituents is still not available. This study evaluated the chemical constituents in vitro and metabolite profiles in vivo of CWXY using ultra\u2010high\u2010performance liquid chromatography (UHPLC) coupled with Q\u2010Exactive Orbitrap mass spectrometry, and the pharmacokinetic behaviors of the nine main components in rats were detected using ultra\u2010high\u2010performance liquid chromatography\u2010triple quadrupole\u2010mass spectrometry (UPLC\u2010QQQ\u2010MS\/MS). A total of 92 chemical constituents in CWXY were preliminarily identified in vitro. After oral administration to rats, 56 prototype components and 128 metabolites of CWXY were detected in the biological samples of rat plasma, urine, bile, and feces. Of these prototype components and metabolites, seven new compounds, namely M15, M16, M25, M30, M31, M71, and M128, were detected for the first time. The quantitation method of nine components in rat plasma was developed using a pharmacokinetic study. To the best of our knowledge, this study was the first to investigate the pharmacokinetic behavior of triumbelletin.<\/jats:p>","DOI":"10.1002\/bmc.5930","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T01:34:40Z","timestamp":1718588080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A comprehensive study of Chuanwang Xiaoyan capsule based on characterization of chemical constituents in vitro and in vivo using ultra\u2010high\u2010performance liquid chromatography\u2010quadrupole\u2010Exactive Orbitrap mass spectrometry and pharmacokinetic study of multiple components in rats using ultra\u2010high\u2010performance liquid chromatography\u2010triple quadrupole\u2010tandem mass spectrometry"],"prefix":"10.1002","volume":"38","author":[{"given":"Yufeng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aichun","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-9611","authenticated-orcid":false,"given":"Jia","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44211-022-00129-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110714"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.03.020"},{"issue":"8","key":"e_1_2_7_5_1","first-page":"973","article-title":"Determination of two ingredients in Chuanwang xiaoyan capsules by HPLC","volume":"26","author":"Deng N.","year":"2006","journal-title":"Chinese Journal of Hospital Pharmacy"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700236"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194957"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201800470"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c19-00662"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.14142\/j.cnki.cn21-1313\/r.2015.01.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2021.122770"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051047"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201401398"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.11.034"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.16720\/j.cnki.tcyj.2021.120"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.114994"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1148332"},{"issue":"32","key":"e_1_2_7_19_1","first-page":"3","article-title":"Clinical effect of amoxicillin clavulanate potassium tablet combined with chuanwang xiaoyan capsule in treating acute pharyngeal tonsillitis","volume":"24","author":"Xiong Y. 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