{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:48:07Z","timestamp":1774493287463,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2024R349"],"award-info":[{"award-number":["RSP2024R349"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Mangifera indica<\/jats:italic><\/jats:styled-content> peels are a rich source of diverse flavonoids and xanthonoids; however, generally these are discarded. Computational studies revealed that mangiferin significantly interacts with amino acid residues of transcriptional regulators 1IK3, 3TOP, and 4f5S. The methanolic extract of Langra variety of mangoes contained the least phenol concentrations (22.6\u2009\u00b1\u20090.32\u2009mg\/gGAE [gallic acid equivalent]) compared to the chloroform (214.8\u2009\u00b1\u20090.12\u2009mg\/gGAE) and ethyl acetate fractions (195.6\u2009\u00b1\u20090.14\u2009mg\/gGAE). Similarly, the methanolic extract of Sindhri variety contained lower phenol concentrations (42.3\u2009\u00b1\u20090.13\u2009mg\/gRUE [relative utilization efficiency]) compared with the chloroform (85.6\u2009\u00b1\u20090.15\u2009mg\/gGAE) and ethyl acetate (76.1\u2009\u00b1\u20090.32\u2009mg\/gGAE) fractions. Langra extract exhibited significant \u03b1\u2010glucosidase inhibition (IC<jats:sub>50<\/jats:sub> 0.06\u2009mg\/mL), whereas the ethyl acetate fraction was highly active (IC<jats:sub>50<\/jats:sub> 0.12\u2009mg\/mL) in Sindhri variety. Mangiferin exhibited significant inhibition (IC<jats:sub>50<\/jats:sub> 0.026\u2009mg\/mL). A moderate inhibition of 15\u2010LOX was observed in all samples, whereas mangiferin was least active. In advanced glycation end product inhibition assay, the chloroform fraction of Langra variety exhibited significant inhibition in nonoxidative (IC<jats:sub>50<\/jats:sub> 64.4\u00a0\u03bcg\/mL) and oxidative modes (IC<jats:sub>50<\/jats:sub> 54.7\u00a0\u03bcg\/mL). It was concluded that both Langra and Sindhri peel extracts and fractions possess significant antidiabetic activities. The results suggest the potential use of peel waste in the management and complications of diabetes.<\/jats:p>","DOI":"10.1002\/bmc.5936","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:31:05Z","timestamp":1719966665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mango peel extracts and mangiferin chromatographic Fourier\u2010transform infrared correlation with antioxidant, antidiabetic, and advanced glycation end product inhibitory potentials using in silico modeling and in vitro assays"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7222-8161","authenticated-orcid":false,"given":"Adnan","family":"Amin","sequence":"first","affiliation":[{"name":"Natural Products Research Lab, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy Gomal University  Dera Ismail Khan 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