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It can effectively inhibit inflammation and tumor migration and has antioxidant activity. In this paper, we establish a simple, fast, sensitive and validated LC\u2013MS method with the purpose of quantification of loganic acid in rat plasma with gliclazide as an internal standard (IS). Methanol was used to precipitate the protein in the plasma sample, and a C<jats:sub>18<\/jats:sub> column (2.1\u2009\u00d7\u200950\u2009mm, 1.7\u00a0\u03bcm) was used for the separation of the target compound. Meanwhile, 0.1% formic acid water\u2013methanol was employed as the mobile phase. Multiple reaction monitoring detection mode was adopted in detection with <jats:italic>m\/z<\/jats:italic> 375.1\u2009&gt;\u2009213.2 for loganic acid and <jats:italic>m\/z<\/jats:italic> 322.1\u2009&gt;\u2009169.9 for the IS, respectively, in negative ion scan mode. The linear range of calibration curve was 5.77\u201311,540.00\u2009ng\/ml, and the lower limit of detedtion was 2.89\u2009ng\/ml. The inter\u2010day and intra\u2010day precision and accuracy were &lt;15% for lower limit of quantitation, low, middle and high quality control samples. This method was successfully used for the pharmacokinetic study of loganic acid in rat plasma at a dose range of 50\u2013150\u2009mg\/kg for oral administration and 2\u00a0mg\/kg for intravenous administration. The pharmacokinetic results showed that the oral bioavailability of loganic acid was low (2.71\u20135.58%).<\/jats:p>","DOI":"10.1002\/bmc.5951","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T01:07:02Z","timestamp":1719968822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A simple and sensitive LC\u2013MS\/MS method for the determination of loganic acid in rat plasma and its pharmacokinetic analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Panpan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-876X","authenticated-orcid":false,"given":"Han","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.09.030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.07.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1681445"},{"key":"e_1_2_7_5_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"Committee of Chinese Pharmacopoeia","year":"2020"},{"issue":"12","key":"e_1_2_7_6_1","article-title":"Loganic acid, an iridoid glycoside extracted from Cornus mas L. fruits, reduces of carbonyl\/oxidative stress biomarkers in plasma and restores antioxidant balance in leukocytes of rats with streptozotocin\u2010induced diabetes mellitus","volume":"10","author":"Dzydzan O.","year":"2020","journal-title":"Life (Basel, Switzerland)"},{"key":"e_1_2_7_7_1","volume-title":"Flora of China","author":"Editorial Committee of Flora of China","year":"2004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104476"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.622772"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121458"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.115085"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA07591A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010233"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110585"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/939402"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.09.024"},{"key":"e_1_2_7_19_1","first-page":"1760","article-title":"In vivo pharmacokinetics of four constituents in Shuanghu Qingan granules in rat plasma","volume":"06","author":"Yu S. 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