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In this study, we have established and validated innovative RP\u2010UPLC methods for assessing ETO and BN in the presence of MP or BA in their dosage forms, employing eight green tools to evaluate their eco\u2010friendliness and effectiveness. Reversed phase\u2010ultra\u2010performance liquid chromatography (RP\u2010UPLC) technique employs a flow rate of 0.3\u00a0mL\/min on Waters Acquity UPLC BEH Column (C18, 1.7\u00a0\u03bcm, 100\u2009mm\u2009\u00d7\u20092.1\u00a0mm), detection at 254\u2009nm using a photo diode array (PDA) detector and mobile phase of 0.05\u2009M KH\n                    <jats:sub>2<\/jats:sub>\n                    PO\n                    <jats:sub>4<\/jats:sub>\n                    buffer, acetonitrile, and methanol (50:15:35, v\/v\/v) adjusted pH\u00a06.0 with 0.2% triethylamine. For ETO, BN, MP, and BA, the calibration curves were linear and ranged from 0.005 to 1.0, from 0.001 to 0.2, from 0.002 to 0.08, and from 0.0001 to 0.1\u00a0mg\/mL, respectively. The correlation value was 0.9999, and the accuracy findings ranged from 98.81% to 100.56%. Consequently, the methodology has been successfully implemented in assay testing for the pharmaceuticals in the presence of the MP or BA, demonstrating the high selectivity of these approaches. The present study presents the Blue Applicability Grade Index (BAGI), an innovative approach that complements green metrics in practical white analytical chemistry. According to the International Council for Harmonisation (ICH) criteria, the procedures were effectively validated.\n                  <\/jats:p>","DOI":"10.1002\/bmc.6006","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T06:14:10Z","timestamp":1726294450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma methodologies"],"prefix":"10.1002","volume":"38","author":[{"given":"Osama A.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Penta Pharma Egypt  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Omran","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science (Men's Campus) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosni A.","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science (Men's Campus) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammena Y.","family":"Binsaleh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University  Riyadh 11671 P.O. Box 84428 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-5465","authenticated-orcid":false,"given":"Mahmoud A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Hikma Pharmaceutical Company  Beni\u2010Suef 62511 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40010-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-023-01028-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2022.110268"},{"key":"e_1_2_7_5_1","unstructured":"British Pharmacopoeia. 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