{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:59:21Z","timestamp":1791917961679,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073971"],"award-info":[{"award-number":["82073971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Panax notoginseng<\/jats:italic> (<jats:italic>P. notoginseng<\/jats:italic>) is one of the most famous natural medicines and widely used to promote blood circulation in health care. However, the active component group of <jats:italic>P. notoginseng<\/jats:italic> for activating blood is not clear. We aim to screen and validate the pharmacodynamic component group (PCG), which could exert the same blood\u2010activating effect as <jats:italic>P. notoginseng<\/jats:italic>. To clarify the active components, the chemical components were determined by liquid chromatography\u2010tandem mass spectrometry, and the fingerprint of <jats:italic>P. notoginseng<\/jats:italic> was established. Twenty candidate active monomers were selected through the spectrum\u2013effect relationship analysis. Eleven active monomers, including Ginsenoside Rg1, Rb1, Rd, F1, Rh1, Rg2, Rb2, Rg3, and Rk1 and Notoginsenoside R1 and R2, were screened out as the PCG through validation by platelet aggregation test. Among them, the antiplatelet aggregation activity of Ginsenoside Rh1 was directly confirmed for the first time. The active component group could exert similar efficacy to the <jats:italic>P. notoginseng<\/jats:italic> extract in\u00a0vitro and in\u00a0vivo through the validation of in\u00a0vitro platelet aggregation test and the rats with cerebral ischemia. This study laid the foundation for the quality evaluation of <jats:italic>P. notoginseng<\/jats:italic> and provided a reference for the research on the material basis of the pharmacodynamics of other Chinese herbs.<\/jats:p>","DOI":"10.1002\/bmc.6083","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T04:17:25Z","timestamp":1737087445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screening and Verification of Blood\u2010Activating Effective Component Group of <i>Panax notoginseng<\/i> Based on Spectrum\u2013Effect Relationships"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1705-2117","authenticated-orcid":false,"given":"Yuqing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lyu","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyve","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-1144","authenticated-orcid":false,"given":"Chunguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chinese Medica Materia Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010021\u201000692\u20102"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.05.061"},{"key":"e_1_2_12_4_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"Commission, C. 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