{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:30:08Z","timestamp":1778956208220,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Corydalis yanhusuo<\/jats:italic> W.T.Wang (YHS) is a commonly used traditional Chinese medicine, often prescribed for treating a variety of pains. In recent years, there has been a gradual increase in the number of reports to liver injury caused by YHS and its preparations, but the exact type and mechanism of hepatotoxicity are still unclear. In the present study, we demonstrated that YHS could induce idiosyncratic drug\u2010induced liver injury (IDILI) in the inflammatory activation models. A total of 459 differential genes and 25 differential metabolites were identified by transcriptomics and metabolomics, which were significantly enriched in the TNF and NF\u2010\u03baB signaling pathways as well as glycerophospholipid metabolism, sphingolipid metabolism, and arachidonic acid metabolism. In addition, YHS significantly increased the levels of TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106. Therefore, we believe that the mechanism of toxicity may be related to the TNF and NF\u2010\u03baB signaling pathways, with glycerophospholipid metabolism, sphingolipid metabolism, and arachidonic acid metabolism also playing important roles. It provides a reference for the safe and rational use of YHS in clinical practice and contributes to the precise prevention and control of the risk of liver toxicity associated with YHS.<\/jats:p>","DOI":"10.1002\/bmc.70093","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:56:32Z","timestamp":1745571392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A New Discovery: <i>Corydalis yanhusuo<\/i> Causes Idiosyncratic Hepatotoxicity and Its Potential Mechanisms"],"prefix":"10.1002","volume":"39","author":[{"given":"Longxin","family":"Guo","sequence":"first","affiliation":[{"name":"School of Pharmacy Dali University  Dali China"},{"name":"Department of Hepatology The Fifth Medical Center of Chinese PLA General Hospital  Beijing Fengtai District 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