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This study aimed to elucidate the potential effect of PG on NAFLD in rats, and furthermore, the mechanism was explored. PG supplementation significantly increased body weight, serum total cholesterol, triglycerides, and LDL\u2010cholesterol levels in HFD\u2010induced obese rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, HFD\u2010induced lipid accumulation and inflammatory response in the liver were also suppressed. Then, the factors contributing to the regulating effect of PG on NAFLD were estimated by using network pharmacology and RNA sequencing. Moreover, western blotting and reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR) suggested that PG treatment obviously downregulated the expression levels of nuclear factor\u2010\u03baB (NF\u2010\u03baB), Toll\u2010like receptor 4 (TLR4), myeloid differentiation primary response protein 88 (MyD88), and inhibitor I kappa B alpha (I\u03baB\u03b1), whereas it upregulated the expression of peroxisome proliferator\u2010activated receptor\u2010gamma (PPAR\u03b3). Taken together, these findings corroborated the modulatory capacity of PG on NAFLD rats through regulating inflammatory response via PPAR\u03b3 and TLR4\/NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1002\/bmc.70111","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T02:55:05Z","timestamp":1747796105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp><i>Platycodon grandiflorum<\/i><\/scp> Attenuates Non\u2010Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPAR\u03b3 and TLR4\/NF\u2010\u03baB Signaling Pathway"],"prefix":"10.1002","volume":"39","author":[{"given":"Ming","family":"Dang","sequence":"first","affiliation":[{"name":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang 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