{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:54:51Z","timestamp":1760061291258,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patent ductus arteriosus (PDA) is a common congenital heart defect in preterm infants and is associated with significant morbidity. Early diagnosis is crucial but challenging due to nonspecific clinical symptoms. This study aims to identify potential metabolomic biomarkers for early detection of PDA using human cord blood. A prospective cross\u2010sectional study was conducted involving 45 preterm infants between 23<jats:sup>0\/6<\/jats:sup> and 31<jats:sup>6\/7<\/jats:sup>\u2009weeks of gestation. The diagnosis of hemodynamically significant PDA (hsPDA) was based on echocardiographic findings after 48\u2009h, showing a left atrium\u2010to\u2010aortic root ratio &gt;\u20091.5 and\/or a ductus diameter &gt;\u20091.5\u2009mm. Untargeted metabolomics analysis was performed on cord blood plasma samples using quadrupole time\u2010of\u2010flight liquid chromatography\u2010mass spectrometry (Q\u2010TOF LC\/MS). Data were processed for metabolites that differed between groups. Twenty infants with hsPDA formed the study group, 25 controls. Out of 4237 detected peaks, 40 showed statistically significant differences (fold change &gt;\u20091.5,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Among these, 15 metabolites were potentially clinically relevant. Key findings included decreased levels of guanidino acetic acid, <jats:italic>S<\/jats:italic>\u2010adenosylmethionine, and ceramides and increased levels of docosahexaenoic acid, arachidonic acid, and cholesterol\u2010related molecules in the PDA group. The study reveals significant metabolic alterations in lipid metabolism and oxidative stress\u2010related pathways in PDA infants. Further targeted metabolomics studies are warranted to validate and explore clinical applications.<\/jats:p>","DOI":"10.1002\/bmc.70125","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:19:20Z","timestamp":1748305160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary Metabolomics Data Reveals Lipid Metabolism and Oxidative Stress Metabolites as Potential Biomarkers for Patent Ductus Arteriosus"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-5512","authenticated-orcid":false,"given":"Mustafa","family":"\u00c7elebier","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aybuke","family":"Yazici","sequence":"additional","affiliation":[{"name":"Division of Neonatology University 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