{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:43:29Z","timestamp":1787237009721,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Lirianthe coco<\/jats:italic>\n                    flowers are an alternative for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Albizia julibrissin<\/jats:italic>\n                    <\/jats:styled-content>\n                    flowers used as anti\u2010insomnia in Guangdong, China. They once shared the name\n                    <jats:italic>yehehua<\/jats:italic>\n                    (YHH) with similar cultural connotations in history. However, no comprehensive studies have been conducted to explore the effective components in YHH and the underlying mechanisms for anti\u2010insomnia. The components in YHH were comprehensively annotated by the classical Global Natural Products Social Molecular Networking (GNPS) and Feature\u2010Based Molecular Network (FBMN) combined with MS\u2010DIAL to improve the accuracy of structural annotation, and the main components were labeled for network pharmacological analysis. Subsequently, the \u201ccompounds\u2013targets\u2013pathways\u201d network was constructed, and molecular docking was adopted to discover effective ingredients of YHH for anti\u2010insomnia. Finally, a total of 103 main components were annotated and summarized. Among them, lignans and flavonoids had similar or the same component category and structures as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009julibrissin<\/jats:italic>\n                    <\/jats:styled-content>\n                    flowers and barks. Particularly, phosphatidylcholines, previously unreported, were found from YHH. The selected effective ingredients could play synergistic roles in inflammation regulation, neuroprotection, and drug combination or assembly utilization. YHH contains effective ingredients for anti\u2010insomnia, which can improve the treatment of insomnia. Some TCMs with common efficacy had a similar substance base.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70131","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:35:05Z","timestamp":1748939705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Strategy for Discovering Effective Ingredients of\n                    <i>Lirianthe coco<\/i>\n                    Flowers (\n                    <i>Yehehua<\/i>\n                    ) for Anti\u2010Insomnia Based on Molecular Networking and Network Pharmacology"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-5005","authenticated-orcid":false,"given":"Changshui","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control Yangzhou University  Yangzhou China"},{"name":"NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and Prepared Slices)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Duan","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and Prepared Slices)  Zhengzhou China"},{"name":"Henan Institute for Drug and Medical Device Inspection  Zhengzhou China"},{"name":"Henan Province Engineering Research Center for Quality Control of Traditional Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"Testing Center Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15540"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i48.9231"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105857"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21608\/rpbs.2023.190923.1211"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4398"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-14093"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2006.2284"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13169362"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.806787"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S114560"},{"key":"e_1_2_9_12_1","volume-title":"Guangdong Provincial Standard of Chinese Medicinal Materials","author":"Guangdong Drug Administration","year":"2018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01045-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45982"},{"key":"e_1_2_9_15_1","first-page":"770","article-title":"Evaluation of DPPH Free Radical Scavenging Activity of Magnolia coco Flowers","volume":"5","author":"Irawan C.","year":"2017","journal-title":"International Journal of Chemical Studies"},{"key":"e_1_2_9_16_1","first-page":"1240","article-title":"Phytochemistry and Chemical Composition by GCMS of n\u2010Hexane and Methanol Extract of Magnolia coco Flowers","volume":"6","author":"Irawan C.","year":"2017","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.066"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2017.1292837"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.39.2952"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211039810"},{"key":"e_1_2_9_21_1","volume-title":"Shenzhen Flora","author":"Li P. Q.","year":"2017"},{"key":"e_1_2_9_22_1","first-page":"2017","article-title":"Network Target: A Starting Point for Traditional Chinese Medicine Network Pharmacology","volume":"36","author":"Li S.","year":"2011","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)80428-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1758-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.521"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-014-0216-2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402101"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.11.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614680114"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11110763"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536595"},{"key":"e_1_2_9_33_1","volume-title":"Pharmacopoeia of People's Republic of China, Part I","author":"The State Commission of Chinese Pharmacopoeia","year":"2020"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3597"},{"key":"e_1_2_9_35_1","unstructured":"WFO.2024. \u201cLirianthe coco(Lour.) N.H. Xia & C.Y. Wu.\u201dhttp:\/\/www.worldfloraonline.org\/taxon\/wfo\u20100000913273 https:\/\/www.iplant.cn\/info\/Lirianthe%20coco?t=z."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00743"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.82.6_816"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117601"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/np970571d"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.199800116"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.02.017"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061380"},{"issue":"1","key":"e_1_2_9_43_1","first-page":"135","article-title":"Polyene Phosphatidylcholine Injection in the Treatment of Alcoholic Liver Disease: A Systematic Review and Meta Analysis","volume":"27","author":"Zeng B. Q.","year":"2024","journal-title":"Zhongguo Yaoshi Zazhi"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c02230"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116306"},{"key":"e_1_2_9_46_1","first-page":"585","article-title":"Analysis of Chemical Constituents of Essential Oils From Guangdong Albizia Flower (Magnolia coco) by GC\u2010MS","volume":"11","author":"Zhao M. H.","year":"2000","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.05.027"},{"key":"e_1_2_9_48_1","first-page":"125","article-title":"Analysis of Chemical Constituents of Essential Oils From Magnolia coco by GC\u2010MS","volume":"17","author":"Zhu X. Y.","year":"2011","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:28:53Z","timestamp":1760048933000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/bmc.70131"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70131","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70131"}}