{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:47:02Z","timestamp":1776523622793,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Jing Dai Ning Jiao Nang (JDNJN), a traditional Miao medicine from Guizhou Province, demonstrates clinical efficacy in treating gynecological disorders like dysmenorrhea but lacks mechanistic clarification. This study investigated JDNJN's anti\u2010cervicitis effects and pharmacological basis using a 25% phenol mucilage\u2010induced rat cervicitis model. The efficacy of JDNJN was evaluated through pathological examination, peripheral blood tests, HE staining, and ELISA assays. UHPLC\u2010Q\u2010TOF\u2010MS\/MS was used to analyze the chemical components of JDNJN, as well as prototype compounds and metabolites in the plasma, urine, and feces of rats after administration. The results showed that JDNJN ameliorated cervicitis\u2010induced alterations in body weight, vulvar inflammation, organ index, white blood cell count, and cervical tissue structure in rats, and exerted therapeutic effects by regulating inflammatory cytokines. Additionally, 98 compounds were identified in JDNJN, primarily flavonoids, with 17 prototype compounds and 60 metabolites detected post\u2010administration. Key metabolic pathways included deoxygenation, hydroxylation, methylation, hydroxylation combined with methylation, and sulfation. These findings establish the anti\u2010inflammatory effect of JDNJN on cervicitis and clarify its pharmacodynamic material basis. This study provides foundational evidence for further exploration of JDNJN's active components and molecular mechanisms.<\/jats:p>","DOI":"10.1002\/bmc.70146","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T03:31:42Z","timestamp":1750131102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacodynamic Substance Basis and Anti\u2010Cervicitis Efficacy Study of Jing Dai Ning Jiao Nang Based on UHPLC\u2010Q\u2010TOF\u2010MS\/MS Technology"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0629-2967","authenticated-orcid":false,"given":"Ling","family":"Yuan","sequence":"first","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Centre for Solid Preparation in Chinese Herbal Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liye","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Feng","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"},{"name":"National Pharmaceutical Engineering Centre for Solid Preparation in Chinese Herbal Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wugang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"Analysis of Chemical Constituents and Components Absorbed Into Blood of Baidoukou Aqueous Extract Based on UPLC\u2010Q\u2010Exactive\u2010Orbitrap MS\/MS","author":"Ba D. 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