{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:49:45Z","timestamp":1760060985698,"version":"build-2065373602"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Yiwei Decoction (YWD), a traditional Chinese medicine for nourishing yin and promoting fluid production, is a potential treatment for dry eye disease (DED). Network pharmacology identifies YWD\u2019s active components and mechanisms for treating DED, while high\u2010performance liquid chromatography (HPLC) detects active compounds in water\u2010prepared YWD extracts. A Box\u2013Behnken design with response surface methodology was used to optimize the extraction of these components. Using this method, acteoside (AC), quercetin (QR), and methylophiopogonanone A (MA) were detected as the main contributors to anti\u2010DED, acting on SRC, AKT1, PIK3CA, and STAT3, which may affect the development of DED through lipid metabolism, atherosclerosis, and PI3K\u2010Akt and MAPK pathways. Based on the analytic hierarchy process, taking the phytochemical composition and the proliferation rate of YWD on human corneal epithelial cells (HCECs) as comprehensive indicators, the best extraction parameters were obtained as liquid\u2013solid ratio of 8\u2009mL\/g, extraction times of 1.636 times, and decocting time of 54.96\u2009min. Verification based on actual conditions, the standardized score is 0.9417\u2009\u00b1\u20090.0386, which is very close to the predicted score of 0.9328, with an error of less than 1%. This reliable method aids in optimizing the extraction process of traditional Chinese medicine for specific diseases.<\/jats:p>","DOI":"10.1002\/bmc.70154","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T02:50:32Z","timestamp":1751079032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of Extraction of Yiwei Decoction by Network Pharmacology Combined With Response Surface Design and Bioactivity Evaluation"],"prefix":"10.1002","volume":"39","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[{"name":"Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zepeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-1799","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.11.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103083.2012.02686.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/512926"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2022.07.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002547\u20102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.13728\/j.1673\u20106427.2022.03.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21826"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715206299886240620070011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092219"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462311000523"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2021.19747"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27082380"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7283"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.27.4.197.16598"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010024\u201000485\u2010w"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030547"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051206"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.70077"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2024.102465"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131696"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2019.1637243"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080873"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108113"},{"key":"e_1_2_8_27_1","first-page":"56","article-title":"Exploring the Mechanism and Function of Xiasangju in the Treatment of Xerophthalmia Based on Network Pharmacology and Experimental Validation","volume":"63","author":"Li J.\u2010L.","year":"2024","journal-title":"Acta Scientiarum Naturalium Universitatis Sunyatseni"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007773"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(23)60429\u20107"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030167"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124558"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.815075"},{"issue":"15","key":"e_1_2_8_33_1","first-page":"483","article-title":"Network Pharmacology Study on the Mechanism of YiWei Soup in the Treatment of Chronic Atrophic Gastritis","volume":"30","author":"Liu S.\u2010L.","year":"2021","journal-title":"Chinese Journal of Ethnomedicine and Ethnopharmacy"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655\u2010015\u20102081\u2010x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090572"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4053"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112659"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4060"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.01.003"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010020\u201000346\u20106"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894\u2010020\u201004356\u2010x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384\u2010011\u20100002\u2010x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20211246"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9304"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1002\u20102619.2020.05.010"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113296"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2024.07.007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.12.014"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.13729\/j.issn.1671\u20107813.Z20210138"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.31857\/S0026898423010196"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad518"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8746895"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2024.10.19"},{"key":"e_1_2_8_54_1","article-title":"BMSC Reduces ROS and Inflammation Levels by Inhibiting TLR4\/MYD88\/NF\u2010\u03baB Signaling Axis to Alleviate Dry Eye","volume":"19","author":"Zhao D.","year":"2023","journal-title":"Research Square"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7316794"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20101296.211029"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.05.004"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:39:32Z","timestamp":1760038772000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/bmc.70154"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70154","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"2025-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70154"}}