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Traditional pharmacodynamic evaluation, serum pharmacochemistry, and metabolomics techniques were used to link changes in pharmacodynamic substances to changes in the metabolism. The results of serum pharmacochemical analysis showed that the \u201cJun\u2010drug\u201d affected the metabolism of 3 components in the \u201cChen\u2010drug,\u201d the absorption of 3 components, and the metabolism of 14 components in the \u201cZuo\u2010drug\u201d; the \u201cChen\u2010drug\u201d affected the absorption of 2 components and the metabolism of 12 components in the \u201cZuo\u2010drug\u201d; and the \u201cZuo\u2010drug\u201d affected the absorption of 2 components and the metabolism of 4 components in the \u201cChen\u2010drug.\u201d The analysis of CAG\u2010related metabolites demonstrated that 11 differential metabolites were significantly regulated by \u201cJun drug,\u201d and 13 differential metabolites were significantly regulated by \u201cChen drug\u201d and \u201cZuo drug.\u201d Molecular docking demonstrated that serum components of high correlation exhibited good binding activity to one or more targets of the differential metabolites. This study was helpful to understand the compatibility mechanism of TCM formulas.<\/jats:p>","DOI":"10.1002\/bmc.70159","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T13:00:55Z","timestamp":1752411655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Compatibility Mechanism of Xiaojianzhong Decoction Intervening in Chronic Atrophic Gastritis Rats Based on Serum Pharmacochemistry and Metabolomics"],"prefix":"10.1002","volume":"39","author":[{"given":"Wentian","family":"Lu","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi 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