{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T18:38:34Z","timestamp":1775414314098,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252235"],"award-info":[{"award-number":["7252235"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation, with current Western treatments focusing on symptom relief and disease progression control through antiinflammatory, analgesic, and immunosuppressive drugs. However, these therapies have significant side effects and limited long\u2010term efficacy. Therefore, novel treatment options are urgently needed. <jats:italic>Lonicerae japonicae<\/jats:italic> Caulis (LJC), a traditional Chinese medicine, has alleviated RA symptoms such as joint pain and swelling. Despite its widespread use, the underlying mechanisms of its therapeutic effects remain poorly understood. This research aimed to uncover the mechanisms by which LJC intervenes in RA, using transcriptomics and energy metabolomics. RA was induced in rats via Type II collagen and incomplete adjuvant. LJC's effects were assessed through joint swelling, TNF\u2010\u03b1 levels, and histopathology. Mechanisms were analyzed using transcriptomics and metabolomics. The role of chlorogenic acid (CGA) was verified in LPS\u2010induced RAW264.7 cells. LJC reduced joint swelling and TNF\u2010\u03b1 levels and inhibited synoviocyte proliferation and angiogenesis. Transcriptomics revealed LJC modulated RA pathways and inflammation. Metabolomics identified <jats:italic>cis<\/jats:italic>\u2010aconitic acid as a key metabolite in energy metabolism. CGA was confirmed as the primary active component. LJC alleviates RA by inhibiting inflammation and modulating energy metabolism through multiple pathways.<\/jats:p>","DOI":"10.1002\/bmc.70175","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:04:46Z","timestamp":1753333486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the Mechanism of <scp><i>Lonicerae japonicae<\/i><\/scp> Caulis in the Treatment of Rheumatoid Arthritis Based on Transcriptomics and Energy Metabolomics"],"prefix":"10.1002","volume":"39","author":[{"given":"Zhenzhen","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of TCM\u2010Information Engineer of State Administration of TCM, School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of 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