{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:12:13Z","timestamp":1771459933129,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this study, a pipette tip solid\u2010phase extraction (PT\u2010SPE) method was developed using cork powder as a natural biosorbent for the extraction of five pharmaceutical contaminants: diclofenac, ibuprofen, ketoprofen, bezafibrate, and fenoprofen. The method was applied to both spiked tap water and real river water samples. The cork powder was characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Brunauer\u2013Emmett\u2013Teller (BET) analysis to assess its functional groups, morphology, and surface properties. The analytes were separated and quantified using reverse\u2010phase high\u2010performance liquid chromatography (RP\u2010HPLC) with UV detection at 226\u2009nm. Method optimization was performed by evaluating key parameters, including the amount of adsorbent, sample volume, and desorption solvent. The developed method demonstrated low limits of detection (LOD) ranging from 0.68 to 1.22\u2009\u03bcg\/L<jats:sup>\u22121<\/jats:sup> and limits of quantification (LOQ) between 2.06 and 3.68\u2009\u03bcg\/L<jats:sup>\u22121<\/jats:sup>. The calibration curves exhibited good linearity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.978\u20130.996) over the concentration range of 5\u2013200\u2009\u03bcg\/L<jats:sup>\u22121<\/jats:sup>. Satisfactory recoveries were obtained, ranging from 80.32% to 103.3%, with relative standard deviations (RSD) below 6.3%. In real river water samples, some analytes were detected even in non\u2010spiked conditions, whereas no contamination was observed in non\u2010spiked tap water.<\/jats:p>","DOI":"10.1002\/bmc.70187","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:04:49Z","timestamp":1754546689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Natural Biosorbents for Detecting Emerging Contaminants in Tap and River Water via Pipette Tip Solid\u2010Phase Extraction (PT\u2010SPE)"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-7924","authenticated-orcid":false,"given":"Hassen","family":"Khazri","sequence":"first","affiliation":[{"name":"Laboratory for Applications of Chemistry to Resources Natural Substances and Environment (LACReSNE). Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Carthage University  Zarzouna Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Touaylia","sequence":"additional","affiliation":[{"name":"Laboratory of Environment Biomonitoring, Life Sciences Department, Faculty of Sciences Bizerte, University of Carthage  Zarzouna Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Trabelsi\u2010Ayadi","sequence":"additional","affiliation":[{"name":"Laboratory for Applications of Chemistry to Resources Natural Substances and Environment (LACReSNE). Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Carthage University  Zarzouna Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riadh","family":"Ternane","sequence":"additional","affiliation":[{"name":"Laboratory for Applications of Chemistry to Resources Natural Substances and Environment (LACReSNE). Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Carthage University  Zarzouna Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissem","family":"ghorbel\u2010abid","sequence":"additional","affiliation":[{"name":"Laboratory for Applications of Chemistry to Resources Natural Substances and Environment (LACReSNE). Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Carthage University  Zarzouna Tunisia"},{"name":"Useful Materials Laboratory (LMU) National Institute for Physical and Chemical Research and Analysis (INRAP)  Ariana Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3144"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.05.062"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2017.06.067"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00218a019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201501241"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.09.026"},{"issue":"566","key":"e_1_2_7_8_1","first-page":"145","article-title":"Disposable Pipette Extraction","volume":"6","author":"Brewer W. E.","year":"2003","journal-title":"US Patent"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.02.049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.07.067"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.06.050"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.02.034"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.11.033"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.09.047"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/w16060814"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NJ40433H"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2016.12.023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.463520"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2010.06.059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960145h"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.09.052"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.05.024"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201801251"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661\u2010011\u20102296\u20106"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.04.033"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2021.338984"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2023.109537"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac950765b"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008\u20106223(98)00303\u20108"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2022.101789"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.01.013"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111693"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010015\u20104844\u20100"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0926\u20102040(95)00028\u2010J"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.02.027"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.08.002"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2016.09.074"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.462470"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2015.01.055"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.12.010"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142675"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200054"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcoa.2024.100156"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:25:34Z","timestamp":1760048734000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/bmc.70187"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70187","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2024-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70187"}}