{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:17:23Z","timestamp":1787793443422,"version":"build-2784847793"},"reference-count":99,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Allium ascalonicum<\/jats:italic><\/jats:styled-content> (shallot) is a traditional medicinal plant recognized for its rich phytochemical content and therapeutic potential. This study aimed to evaluate the phytochemical composition, antidiabetic activity, and toxicity profile of the ethyl acetate fraction and essential oil. GC\u2013MS analysis identified 34 compounds in the ethyl acetate fraction, with major constituents including phenol, 2\u2010methoxy\u20104\u2010vinyl\u2010 (17.77%) and 2\u2010cyclohexene\u20101\u2010one (7.99%), while the essential oil revealed 10 major compounds such as hexadecanoic acid, methyl ester (30.77%), and caryophyllene oxide (10.82%). Phytochemical screening confirmed the presence of flavonoids, alkaloids, tannins, saponins, and terpenoids. Heavy metal analysis indicated acceptable levels, with lead and cobalt undetected. In\u00a0vitro antidiabetic assays demonstrated potent \u03b1\u2010amylase, DPP\u20104, and PTP\u20101B inhibitory activity, especially by the essential oil (IC<jats:sub>50<\/jats:sub>\u2009=\u20097.93, 7.74, and 17.86\u2009\u03bcg\/mL), comparable with standard drugs. Acute toxicity studies revealed no adverse effects up to 2000\u2009mg\/kg. In\u00a0vivo, both the ethyl acetate fraction and essential oil significantly reduced fasting blood glucose (over 40%), improved lipid profiles, and prevented weight loss in streptozotocin\u2010induced diabetic mice. Further studies focusing on molecular targets and signaling pathways are warranted to fully elucidate the therapeutic potential of <jats:styled-content style=\"fixed-case\"><jats:italic>A. ascalonicum<\/jats:italic><\/jats:styled-content> in diabetes management.<\/jats:p>","DOI":"10.1002\/bmc.70193","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T03:46:37Z","timestamp":1755488797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytochemical Profiling and Dual In\u00a0Vitro In\u00a0Vivo Antidiabetic Assessment of Ethyl Acetate Fraction and Essential Oil From <scp><i>Allium ascalonicum<\/i><\/scp>"],"prefix":"10.1002","volume":"39","author":[{"given":"Aftab\u00a0Ahmad","family":"Khan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Gomal University D. I. Khan  Dera Ismail Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazal\u00a0Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Gomal University D. I. Khan  Dera Ismail Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8794-9242","authenticated-orcid":false,"given":"Madeeha","family":"Shabnam","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Chemical Sciences University of Peshawar  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fida","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-6510","authenticated-orcid":false,"given":"Muhammad\u00a0Saeed","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bacha Khan University  Charsadda Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5584-1912","authenticated-orcid":false,"given":"Atta\u00a0Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Botany Islamia College Peshawar  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-3466","authenticated-orcid":false,"given":"Eman\u00a0R.","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Center for Health Research Northern Border University  Arar Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Anti\u2010Diabetic Effects of Plant Extracts in STZ\u2010Induced Diabetic Models","volume":"320","author":"Abdulmalek S.","year":"2024","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"195","article-title":"Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Neglected Tropical Diseases in Nigeria","volume":"148","author":"Adefioye A. 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