{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:18:10Z","timestamp":1773080290205,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Phoenix dactylifera<\/jats:italic><\/jats:styled-content> L. (Ghars variety) seeds, widely available in Algeria, represent a valuable natural resource. Their rich phytochemical composition presents promising potential for applications in health and skincare. This study evaluates the phytochemical profile and biological activities of ethanolic extracts (EE) from Ghars date seeds and assesses the antimicrobial efficacy of a formulated cosmetic cream. Ethanolic extraction yielded 11.425% EE. Phytochemical screening, total flavonoid content (TFC), and total phenolic content (TPC) were determined. Antioxidant activity was evaluated using ferric reducing antioxidant power (RAP) and DPPH assays. Anti\u2010inflammatory activity was assessed via membrane stabilization, and the antimicrobial potential of the EE\u2010based cream was tested against selected bacterial strains. The EE exhibited high flavonoid (68.81\u2009mg\/mL) and phenolic content (118.6\u2009mg\/mL). Antioxidant assays showed strong activity, with IC<jats:sub>50<\/jats:sub> values of 47.86\u2009\u03bcg\/mL (FRAP) and 35.85\u2009\u03bcg\/mL (DPPH). The extract demonstrated notable anti\u2010inflammatory effects. The EE\u2010based cream displayed significant antimicrobial activity, with inhibition zones up to 27\u2009mm against <jats:styled-content style=\"fixed-case\"><jats:italic>Bacillus subtilis<\/jats:italic><\/jats:styled-content> and marked effects against <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Pseudomonas aeruginosa<\/jats:italic><\/jats:styled-content>. Ghars date seed EE shows strong antioxidant, anti\u2010inflammatory, and antimicrobial properties, supporting its use as a natural ingredient in cosmetic and healthcare formulations.<\/jats:p>","DOI":"10.1002\/bmc.70199","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T03:46:39Z","timestamp":1755488799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Analysis and Bioactivity Evaluation of <scp><i>Phoenix dactylifera<\/i><\/scp> L. Ethanolic Extract and Cosmetic Cream: Antibacterial, Antioxidant, and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"39","author":[{"given":"Inasse","family":"Cherfi","sequence":"first","affiliation":[{"name":"Faculty of Natural Science and Life, Department of Molecular and Cellular Biology El Oued University  El\u2010Oued Algeria"},{"name":"Laboratory Biology, Environment, and Health, Faculty of Natural Sciences and Life El\u2010Oued University  El\u2010Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abir","family":"Benaissa","sequence":"additional","affiliation":[{"name":"BBCM laboratory, Department of process engineering and petrochemistry, Faculty of Technology University of El Oued  El\u2010Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasma","family":"Mahboub","sequence":"additional","affiliation":[{"name":"Faculty of Natural Science and Life, Department of Molecular and Cellular Biology El Oued University  El\u2010Oued Algeria"},{"name":"Laboratory Biology, Environment, and Health, Faculty of Natural Sciences and Life El\u2010Oued University  El\u2010Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u00a0Taher","family":"Benmoussa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Department of Pharmacy, Faculty of Medicine University of Batna  Batna Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inas","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Faculty of Natural Science and Life, Department of Molecular and Cellular Biology El Oued University  El\u2010Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brahim","family":"Dif","sequence":"additional","affiliation":[{"name":"Faculty of Natural Science and Life, Department of Molecular and Cellular Biology El Oued University  El\u2010Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikram","family":"Djaber","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Department of Pharmacy, Faculty of Medicine University of Batna  Batna Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-4150.2020.00007.3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssas.2018.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400456"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.10.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12091415"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-022-03952-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nfs.2021.01.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.25130\/tjps.v21i1.949"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12576"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020238"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf302602v"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0308879"},{"key":"e_1_2_6_14_1","unstructured":"Ansari A. 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