{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:50:14Z","timestamp":1789055414099,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Syringa oblata<\/jats:italic>\n                    <\/jats:styled-content>\n                    Lindl. leaf extract has a long history of use with pharmacological properties such as heat\u2010clearing, detoxifying, and anti\u2010inflammatory effects. In this study, an ulcerative colitis (UC) animal model was established and compared with a normal group. The study simultaneously determined 6 components of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. oblata<\/jats:italic>\n                    <\/jats:styled-content>\n                    Lindl. leaf extract (protocatechuic acid, caffeic acid, quercetin 3\u2010O\u2010\u03b2\u2010D\u2010glucopyranoside, (8E)\u2010ligstroside, oleuropein, and oleacein) in the plasma of rats. The results showed that the extract exhibited good biological utilization in both groups, with stable metabolism of the six components, maintaining effective plasma concentrations. Pharmacokinetic analysis suggested the extract's potential for UC treatment. The relative standard deviation (RSD) of precision and accuracy for the six components was below 13%, and the lower limits of quantification (LLOQ) were 5.10, 5.10, 10.2, 10.1, 3.39, and 3.18\u2009ng\/mL, respectively. The method met FDA bioanalytical validation criteria for stability, matrix effects, and extraction recovery. Significant pharmacokinetic differences between UC and normal rats were observed, highlighting the extract's potential for clinical application and health product development, offering a promising therapeutic option for UC.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70245","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:27:46Z","timestamp":1761658066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous Determination of Six Compounds by UHPLC\u2013MS\/MS: Comparison of Pharmacokinetics of\n                    <scp>\n                      <i>Syringa oblata<\/i>\n                    <\/scp>\n                    Lindl. Leaf Extract in Normal and Ulcerative Colitis Rats After Oral Administration"],"prefix":"10.1002","volume":"39","author":[{"given":"Shulu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Acupuncture Moxibustion and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Materia Medica (Ministry of Education) Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiu","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinze","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-7167","authenticated-orcid":false,"given":"Chunjuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-745X","authenticated-orcid":false,"given":"Chunli","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.08.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131351"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081927"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202000514"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.09.019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700981"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.114858"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20200224.202"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16119451"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.123.001400"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.074"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154544"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.11.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1366"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2022.04.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1197"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2023.2270741"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300282"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.01.036"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.04.054"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1269"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13809"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.018"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500756"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.577656"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:52:39Z","timestamp":1764420759000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/bmc.70245"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70245","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"2025-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70245"}}