{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:54:51Z","timestamp":1764420891702,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070384","21502165"],"award-info":[{"award-number":["32070384","21502165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Blachia pentzii<\/jats:italic>\n                    has no history of ethnic or folk medicinal use. Its medicinal value deserves further exploration. Currently, the molecular networking (MN) technology and network pharmacology methods contribute to exploring the potential medicinal value of plants with relatively few reported chemical components. In the present study, we provided a method for rapid analysis of chemical constituents in\n                    <jats:italic>Blachia pentzii<\/jats:italic>\n                    leaves (\n                    <jats:italic>BPL<\/jats:italic>\n                    ) and a network pharmacology study of rheumatoid arthritis (RA), especially when the identification is limited by the MN technology. Finally, a total of 64 components were annotated, including structural types such as terpenoids, phenolic acids, steroids, fatty acid derivatives, and phospholipids. Network pharmacological analysis revealed that the chemical constituents of\n                    <jats:italic>BPL<\/jats:italic>\n                    exert anti\u2010RA effects by acting on 56 core targets, including IL6, TP53, TNF, STAT3, and BCL2, and regulating signaling pathways such as Proteoglycans in cancer, HIF\u20101 signaling pathway, Lipid and atherosclerosis, and AGE\u2010RAGE signaling pathway in diabetic complications. The selected effective ingredients could play synergistic roles in anti\u2010RA, indicating that\n                    <jats:italic>BPL<\/jats:italic>\n                    contains anti\u2010RA effective ingredients and that the relevant active substances have the potential to be developed into anti\u2010RA drugs and deserve in\u2010depth research in chemistry and pharmacology.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70248","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:12:19Z","timestamp":1761412339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Analysis of Chemical Constituents in\n                    <i>Blachia pentzii<\/i>\n                    Leaves and Predictive Analysis of the Pharmacological Effects for Treatment of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"39","author":[{"given":"Yanyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"Testing Center Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilin","family":"Pu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tao","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control (Yangzhou University)  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control (Yangzhou University)  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-5005","authenticated-orcid":false,"given":"Changshui","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, School of Medicine Yangzhou University  Yangzhou China"},{"name":"The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control (Yangzhou University)  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c00301"},{"key":"e_1_2_8_3_1","unstructured":"Li P. T. andM. G.Gilbert.2008. \u201cBlachia.\u201d Flora of China 11: 269\u2013270.http:\/\/www.iplant.cn\/foc\/pdf\/Blachia.pdf."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010019\u20101758\u20104"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"106","article-title":"Chemical Constituents of Ethanol Extract From the Leaves of Blachia pentzii","volume":"34","author":"Pu Z. L.","year":"2025","journal-title":"Journal of Plant Resources and Environment"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11110763"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010136\u201012\u2010200206180\u201000012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3597"},{"key":"e_1_2_8_9_1","first-page":"51","volume-title":"The Families and Genera of Vascular Plants","author":"Webster G. L.","year":"2014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114035"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2023.133331"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.70131"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"380","article-title":"Two New Terpenoids From the Leaves of Blachia pentzii","volume":"55","author":"Yang C. S.","year":"2024","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116306"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1394108"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:52:21Z","timestamp":1764420741000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/bmc.70248"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70248","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70248"}}