{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:46:45Z","timestamp":1787168805972,"version":"build-2736575974"},"reference-count":102,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vinblastine (VBL) and vincristine (VCR) are vinca alkaloids derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Catharanthus\u2009roseus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and are among the most widely used chemotherapeutic agents for treating hematological malignancies and solid tumors. Due to their narrow therapeutic index and complex structural nature, accurate, sensitive, and selective analytical methods are crucial for quantifying these drugs in pharmaceutical formulations, biological matrices, and environmental samples. This review provides a comprehensive overview of reported analytical techniques for VBL and VCR, drawing on major databases such as Scopus, Web of Science, ScienceDirect, PubMed, and Google Scholar, with a focus on the English\u2010language literature. The discussed methods include chromatographic, spectroscopic, electroanalytical, and capillary electrophoretic techniques. High\u2010performance liquid chromatography (HPLC), particularly when coupled with LC\u2013MS\/MS, offers exceptional sensitivity, with detection limits as low as 0.025\u2009ng\/mL in plasma. Conventional HPLC\u2010UV methods, though less sensitive, remain widely applied in plant extract analysis. Electroanalytical approaches, such as voltammetry using nanomaterial\u2010modified electrodes, offer eco\u2010friendly and cost\u2010effective alternatives with detection limits as low as 0.3\u2009nM. Key analytical considerations include light sensitivity, pH and temperature control, and matrix interferences. Overall, recent methodological advancements enable reliable quantification of VBL and VCR, supporting safer clinical application, toxicity monitoring, and environmental surveillance.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70262","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:30:11Z","timestamp":1764657011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive Review of Analytical Approaches for Vinblastine and Vincristine in Cancer Research"],"prefix":"10.1002","volume":"40","author":[{"given":"Hemn\u00a0A.\u00a0H.","family":"Barzani","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science College of Health Science, Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-6071","authenticated-orcid":false,"given":"Rebaz\u00a0Anwar","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Health Koya University  Kurdistan Region Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalamala\u00a0Ibrahim\u00a0Salih","family":"Barzani","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mergasor Technical Institute Erbil Polytechnic University  Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanco\u00a0Hassan","family":"Jawhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Health Sciences, Hawler Medical University  Erbil Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seerwan\u00a0Hamadameen","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science College of Health Science, Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoshyar\u00a0Saadi","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Van Yuzuncu Yil University  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1060706"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.36077\/kjas\/2024\/v16i3.11847"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.11.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-51620-2_11"},{"key":"e_1_2_11_6_1","first-page":"2","article-title":"Interaction Studies of Vinblastine Drug With Human Serum Albumin (HSA) by Spectroscopic and Molecular Modeling Studies","volume":"1","author":"Al\u2013Asbahy W. 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