{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T15:51:07Z","timestamp":1766073067791,"version":"3.48.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renshen Zaizao Wan (RSZZW), a traditional Chinese patent drug originated in Qing dynasty, has been used clinically in China to treat stroke. It consists of 65 different types of plant\u2010, animal\u2010, and mineral\u2010derived Chinese medicinal herbs. However, current quality control of RSZZW mainly relies on a thin\u2010layer chromatography (TLC) method. It is difficult to perform quality assessment for this complicated Chinese patent drug. Therefore, the goal of this study is to simplify the identification process and provide a more comprehensive quality assessment method for RSZZW by developing an integrated strategy based on headspace\u2013gas chromatography\u2013ion mobility spectrometry (HS\u2013GC\u2013IMS) and multivariate statistical analysis. Forty\u2010six batches of commercial RSZZW from six different manufacturers were qualitatively analyzed. A total of 129 volatile signals were detected, of which 85 volatile organic compounds were identified, including 19 esters, 15 ketones, 11 terpenes, 11 alcohols, six aldehydes, and several others. By assessment of the ion mobility global profile, the samples from different manufacturers can be well distinguished by principal component analysis.<\/jats:p>","DOI":"10.1002\/bmc.70271","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:03:01Z","timestamp":1764316981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Chemical Profiling and Quality Assessment of Renshen Zaizao Wan by HS\u2010GC\u2010IMS Combined With Chemometrics"],"prefix":"10.1002","volume":"40","author":[{"given":"Wu","family":"Bi","sequence":"first","affiliation":[{"name":"Hunan Institute for Drug Control  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Institute for Drug Control  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehan","family":"Pei","sequence":"additional","affiliation":[{"name":"Zhuzhou Qianjin Pharmaceutical Co., Ltd.  Zhuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyan","family":"Tan","sequence":"additional","affiliation":[{"name":"Chenzhou Center for Food and Drug Control  Chenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5127-3273","authenticated-orcid":false,"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Hunan Institute for Drug Control  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Ding","sequence":"additional","affiliation":[{"name":"Hunan Institute for Drug Control  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Institute for Drug Control  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"volume-title":"Pharmacopoeia of the People's Republic of China","year":"2020","author":"Chinese Pharmacopoeia Commission","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.02.047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067818\u20109"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.01.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111072"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3303\/CET1654014"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"65","article-title":"Identification of the Chinese Patent Medicine ZaiZao Wan(Restorative pills)","volume":"19","author":"Wang Q.","year":"1982","journal-title":"Journal of Nanjing College of Pharmacy"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.126158"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11223745"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2021.106527"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115910"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2022.01115"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T15:49:01Z","timestamp":1766072941000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/bmc.70271"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70271","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70271"}}