{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T15:52:01Z","timestamp":1766073121281,"version":"3.48.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260751"],"award-info":[{"award-number":["82260751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160824"],"award-info":[{"award-number":["82160824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Utilizing active ingredients to inhibit the formation of N\n                    <jats:sup>\u03b5<\/jats:sup>\n                    \u2010carboxymethyllysine (CML) and alleviate CML\u2010induced inflammation damage is crucial for treating diabetic nephropathy caused by CML. In the present study, we aimed to investigate the inhibitory effect and mechanism of naringenin (Nar) on the formation of CML and CML\u2010induced inflammation damage in RAW 264.7 cells. The results indicated that Nar could dose\u2010dependently inhibit the formation of CML in the system of L\u2010lysine and glyoxal (GO) by producing mono\u2010GO\u2010Nar, as evidenced by liquid chromatography coupled to tandem mass spectrometry (LC\u2013MS\/MS). Furthermore, CML\u2010induced inflammatory injury in RAW 264.7 cells was alleviated by Nar through the reduction of gene expression levels of TNF\u2010\u03b1 and IL\u20106. Further mechanistic studies suggested that Nar inhibited inflammatory injury via the AGEs\/RAGE\/NF\u2010\u03baB pathway. In summary, our results initially demonstrated that Nar could inhibit the formation of CML and alleviate CML\u2010induced inflammation, which might represent a novel mechanism by which Nar combats chronic diseases where CML plays a significant role.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70274","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:29:02Z","timestamp":1764548942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naringenin Inhibits the Formation of N\n                    <sup>\u03b5<\/sup>\n                    \u2010Carboxymethyllysine and Ameliorates Inflammation Induced by it in RAW 264.7 Cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Lingxia","family":"Xu","sequence":"first","affiliation":[{"name":"The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixian","family":"Zhou","sequence":"additional","affiliation":[{"name":"The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-5422","authenticated-orcid":false,"given":"Ting","family":"Tan","sequence":"additional","affiliation":[{"name":"The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education Jiangxi University of Chinese Medicine  Nanchang 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