{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:13:51Z","timestamp":1793884431963,"version":"4.7.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Banxia Xiexin Decoction (BXD), a classic traditional Chinese medicine formula traditionally used for gastrointestinal disorders, has demonstrated considerable therapeutic potential in ulcerative colitis (UC). Yet, its mechanism of action remains incompletely elucidated. In this study, we applied an integrated strategy incorporating UPLC\u2010Q\u2010TOF\/MS\u2010based plasma metabolomics and gut microbiome analysis to explore the anti\u2010UC effects of BXD. In a DSS\u2010induced murine model of UC, BXD treatment mitigated colonic inflammation, as evidenced by reduced levels of pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1), repaired intestinal barrier integrity, and restored metabolic homeostasis via regulation of tryptophan and nitrogen metabolism. Notably, BXD promoted the production of microbially derived tryptophan metabolites, including indole\u20103\u2010propionic acid (IPA) and indole\u20103\u2010carboxaldehyde (IAld). IAld acts as a ligand for the aryl hydrocarbon receptor (AhR), facilitating the differentiation and function of regulatory T cells (Tregs) and thereby helping to suppress excessive inflammation. Gut microbiota analysis further indicated that BXD enriched beneficial genera such as\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , while reducing the abundance of pro\u2010inflammatory bacteria belonging to the\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    family. These results demonstrate the role of BXD in modulating the flora\u2010metabolite\u2010inflammation axis, providing a scientific rationale for its use in UC and highlighting its multi\u2010target actions involving anti\u2010inflammatory effects, metabolic reprogramming, and microbiota restoration.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70275","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:25:26Z","timestamp":1764548726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Banxia Xiexin Decoction Ameliorates Ulcerative Colitis via a Flora\u2010Metabolite\u2010Inflammation Axis Through Integrated Metabolomic and Microbiome Analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"Feng","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Anus and Intestine Surgery Yongkang First People's Hospital Affiliated to Hangzhou Medical College  Yongkang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anus and Intestine Surgery Yongkang First People's Hospital Affiliated to Hangzhou Medical College  Yongkang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-4303","authenticated-orcid":false,"given":"Xiangwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anus and Intestine Surgery Yongkang First People's 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