{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:37Z","timestamp":1790802817922,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20370"],"award-info":[{"award-number":["U22A20370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Viscum coloratum<\/jats:italic>\n                    (Kom.) Nakai, a traditional Chinese medicine for rheumatoid arthritis, faces emergency challenges in clinical quality control due to inconsistent formulations and the lack of standardized evaluation criteria. To resolve this issue, this study established a systematic quality control framework for\n                    <jats:italic>Viscum coloratum<\/jats:italic>\n                    (Kom.) Nakai based on the concept of quality markers (Q\u2010markers) in traditional Chinese medicine (TCM). Following TCM Q\u2010markers principles, 10 potential candidates identified in our previous study were selected based on the key criteria, including effective separation and high abundance. A comprehensive five\u2010dimensional evaluation system, for assessing reproducibility, content, stability, relevance, and effectiveness, was developed using an integrated analytic hierarchy process (AHP) and technique for order preference by similarity to ideal solution (TOPSIS) methodologies. Data normalization and weighted scoring facilitated the construction of a \u201cspider\u2010web\u201d model for multicriteria decision\u2010making, with a relative proximity threshold (\u2265\u20090.409) applied to identify the most suitable Q\u2010markers. Finally, through this approach, four candidates were ultimately selected as Q\u2010markers for\n                    <jats:italic>Viscum coloratum<\/jats:italic>\n                    (Kom.) Nakai: viscumneoside III (VIS), homoeriodictyol\u20107\u2010O\u2010\u03b2\u2010glucoside (HOG), oleanolic acid (OLA), and chlorogenic Acid (CHL). This systematic approach enhances\n                    <jats:italic>Viscum coloratum<\/jats:italic>\n                    (Kom.) Nakai quality control and provides insights for TCM standardization.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70277","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T01:19:30Z","timestamp":1764551970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Q\u2010Markers of\n                    <i>Viscum coloratum<\/i>\n                    (Kom.) Nakai: Enhancing Clinical Efficacy for the Treatment of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"40","author":[{"given":"Zhichao","family":"Hao","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Agriculture Northeast Agricultural University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Agriculture Northeast Agricultural University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixue","family":"Kuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-775X","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00054-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5618"},{"issue":"24","key":"e_1_2_9_4_1","first-page":"4313","article-title":"Research on Chemical Constituents From Branches and Twigs With Leaves of Viscum coloratum","volume":"47","author":"Cao D.","year":"2016","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.865066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1837816"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354221118332"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.11.005"},{"issue":"7","key":"e_1_2_9_9_1","first-page":"645","article-title":"Polysaccharides From Fresh Viscum album L. 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