{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:02:39Z","timestamp":1783573359776,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study used untargeted metabolomics via UHPLC\u2010Q\u2010Orbitrap HRMS to compare chemical composition differences between the Chinese medicinal herb\n                    <jats:italic>Spatholobus suberectus<\/jats:italic>\n                    Dunn (Jixueteng) and its common adulterants (\n                    <jats:italic>Mucuna macrocarpa<\/jats:italic>\n                    ,\n                    <jats:italic>Callerya dielsiana<\/jats:italic>\n                    ,\n                    <jats:italic>Kadsura heteroclita<\/jats:italic>\n                    ), aiming to clarify their metabolic profiles. Multivariate statistical analyses (PCA, OPLS\u2010DA), volcano plot analysis, and KEGG pathway enrichment were employed to identify differential metabolites and related pathways. A total of 1157 compounds were identified, predominantly flavonoids, followed by phenolic acids and alkaloids. Significant differential metabolites were screened using VIP &gt;\u20091 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05. For\n                    <jats:italic>S. suberectus<\/jats:italic>\n                    vs.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. macrocarpa<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:italic>C. dielsiana<\/jats:italic>\n                    , differential metabolites were mainly enriched in flavonoid and anthocyanin biosynthesis pathways. In contrast, those between\n                    <jats:italic>S. suberectus<\/jats:italic>\n                    and\n                    <jats:italic>K. heteroclita<\/jats:italic>\n                    concentrated in four pathways: metabolic pathways, secondary metabolite biosynthesis, flavonoid biosynthesis, and flavone\/flavonol biosynthesis. These findings reveal interspecific metabolic profile differences, laying a data foundation for developing characteristic chemical marker\u2010based identification techniques. This supplements existing methods and enhances medicinal material quality control.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70290","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T05:41:46Z","timestamp":1765863706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Potential of UHPLC\u2010Q\u2010Orbitrap HRMS\u2010Based Untargeted Metabolomics for Discriminating\n                    <i>Spatholobus suberectus<\/i>\n                    Dunn From Its Adulterants"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2134-7190","authenticated-orcid":false,"given":"Qiyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbei","family":"Teng","sequence":"additional","affiliation":[{"name":"Guangxi University of Chinese Medicine  Nanning China"},{"name":"Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine  Nanning China"},{"name":"University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials  Nanning China"},{"name":"The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine  Nanning China"},{"name":"Guangxi Engineering Research Center of Ethnic Medicine Resources and Application  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouwei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi University of Chinese Medicine  Nanning 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