{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:09:29Z","timestamp":1769882969834,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB206047"],"award-info":[{"award-number":["20224ACB206047"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lomatogonium rotatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    (L.) Fries ex Nym. is one of the traditional Mongolian medicines in the \u201cDigeida\u201d category. It has the effects of calming Xieri (a concept in Mongolian medicine) and clearing heat and promoting diuresis and is used for the treatment of diseases such as fever, headache, plague, typhoid, jaundice, and liver and gallbladder heat. However, the mechanism of its flavonoid compounds in the treatment of non\u2010alcoholic fatty liver disease (NAFLD) is not yet clear. In this study, a NAFLD mouse model was established by feeding mice with a choline\u2010deficient high\u2010fat (CDHF) diet for 8\u2009weeks. The relevant indicators in the serum and tissues of mice in each group were measured. The compounds in the L\u201030 elution fraction were identified by LC\u2010MS technology, and the liver metabolomics was determined. The results showed that the L\u201030 elution fraction was an enrichment site of flavonoid compounds, and the L\u201030 elution fraction could effectively alleviate lipid deposition in the liver of NAFLD mice and relieve liver metabolic disorders.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70323","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:24:05Z","timestamp":1768382645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Effect and Mechanism of\n                    <scp>\n                      <i>Lomatogonium rotatum<\/i>\n                    <\/scp>\n                    (L.) Fries ex Nym Extract on NAFLD Through Metabolomics"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3821-5136","authenticated-orcid":false,"given":"Xinyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Gao","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoling","family":"Bai","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"},{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang China"},{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726\u2010017\u20102412\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010111622\u2010091232"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010018\u20101506\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2023.04.024"},{"issue":"10","key":"e_1_2_11_6_1","first-page":"1329","article-title":"Study on the Protective Effect of Aqueous Extract of Mongolian Medicine Lomatogonium rotatum (L.) Fries ex Nym Carpaticum on Acute Liver Injury Induced by D\u2010GlaN and CCl4 in Mice","volume":"27","author":"Bao M.","year":"2016","journal-title":"China Pharmacy"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100237"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000314"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171267"},{"key":"e_1_2_11_11_1","article-title":"Site\u2010Specific PCR Identification Study of Raw Medicinal Materials of \u201cDige'da\u201d Mongolian Traditional Chinese Medicines","volume":"40","author":"Cui Z.","year":"2015","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084325"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109581"},{"key":"e_1_2_11_14_1","unstructured":"Eni R.2022. \u201cResearch on Multi\u2010Index Content Determination Preparation Process ofLomatogonium rotatum(L.) Fries ex Nym and Its Protective Effect on Non\u2010Alcoholic Fatty Liver.\u201d Master's thesis Inner Mongolia Minzu University.https:\/\/doi.org\/10.27228\/d.cnki.gnmmu.2022.000330."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010022\u201000635\u20105"},{"key":"e_1_2_11_16_1","volume-title":"Magnoliophyta, Dicotyledoneae, Gentianaceae","author":"He T.","year":"1988"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101238"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000639\u20103"},{"key":"e_1_2_11_19_1","unstructured":"Ji X.2021. \u201cResearch on the Effects of Mongolian MedicineLomatogonium rotatum(L.) Fries ex Nym on Gut Microbiota and Nutrient Absorption in High\u2010Fat Diet\u2010Induced Obese Mice and Its Weight\u2010Loss Mechanism.\u201d Master's thesis Inner Mongolia Minzu University.https:\/\/doi.org\/10.27228\/d.cnki.gnmmu.2021.000040."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M087056"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2009.07.004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910745"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2019.00051"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1426"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.13863\/j.issn1001\u20104454.2024.09.015"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc35577"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.12.017"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000054662.44688.9A"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2600207"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007955"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.381723"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107827(88)90005\u201077"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700278\u2010JLR2000"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.16438\/j.0513\u20104870.2022\u20100624"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038290\u20102"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100014\u20109"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.13.1"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100094\u20106"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201042358\u2010w"},{"issue":"20","key":"e_1_2_11_47_1","first-page":"2538","article-title":"Study 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