{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:13:35Z","timestamp":1789449215081,"version":"build-2803163510"},"reference-count":96,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pravastatin (PRV), a highly hydrophilic statin used to treat hypercholesterolemia and prevent cardiovascular disease, presents certain analytical challenges due to its low bioavailability, tendency to lactonize, and potentially complex metabolism. This review aims to consolidate and critically evaluate the analytical procedures developed for the determination of PRV and its metabolites in pharmaceutical and biological matrices. This review aims to comprehensively summarize four decades of analytical methodologies developed for PRV and its metabolites, comparing chromatographic, spectroscopic, electrochemical, and capillary electrophoresis approaches in terms of sensitivity, selectivity, and matrix applicability. This review also evaluates essential bioanalytical nuances, including PRV's lactone\u2013acid interconversion, matrix\u2010induced ion suppression, pH\u2010dependent instability, low ng\u2013pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    plasma levels, and metabolite\u2010specific detection challenges alongside pharmaceutical analytical considerations. The literature demonstrates that liquid chromatography\u2013tandem mass spectrometry and high\u2010performance liquid chromatography remain the most sensitive and reliable platforms for ultratrace bioanalysis, while spectrophotometric and electrochemical methods provide cost\u2010effective alternatives for formulations and higher concentration samples, and capillary electrophoresis offers efficient separation with low solvent use. Future analytical advances should prioritize metabolite\u2010resolved quantification, green extraction strategies, microfluidic and point\u2010of\u2010care designs, and AI\u2010assisted data processing to improve sensitivity, stability assessment, and high\u2010throughput monitoring of PRV in clinical and environmental settings.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70335","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:07:35Z","timestamp":1768208855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analytical Techniques for the Quantification of Pravastatin and Its Metabolites in Various Matrices: A Comprehensive Review"],"prefix":"10.1002","volume":"40","author":[{"given":"Hemn\u00a0A.\u00a0H.","family":"Barzani","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, College of Health Science Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-6071","authenticated-orcid":false,"given":"Rebaz\u00a0Anwar","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science &amp; Health Koya University  Koya Kurdistan Region \u2013 F.R. Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalamala\u00a0Ibrahim\u00a0Salih","family":"Barzani","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mergasor Technical Institute Erbil Polytechnic University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanco\u00a0Hassan","family":"Jawhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Health Sciences Hawler Medical University  Erbil Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seerwan\u00a0Hamadameen","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Health Science Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoshyar\u00a0Saadi","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"584","article-title":"Ultra Performance Liquid Chromatography Determination of Pravastatin Sodium in Erythrocytes","volume":"24","author":"Abdel\u2010Hamid M.","year":"2012","journal-title":"Asian Journal of Chemistry"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-97072016000200022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5AY00446B"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2021.00129.3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2010.06.050"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2008.4135"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"48","article-title":"Stability Indicating HPLC Method for the Simultaneous Quantification of Aspirin and Pravastatin in Bulk and Tablets: Method Development and Validation","volume":"7","author":"Athota R. V.","year":"2017","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.14227\/DT180111P12"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2025.2511141","article-title":"Quantifying Nitrosoureas: Comprehensive Insights Into Analytical Techniques Transforming Cancer Research","author":"Barzani H. A.","year":"2025","journal-title":"Critical Reviews in Analytical Chemistry"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2298\/JSC240221090B"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2025.111995"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diamond.2022.109658"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.01.006"},{"issue":"1","key":"e_1_2_12_15_1","first-page":"23","article-title":"Development and Validation of pH Independent Spectrophotometric Method for Determination of Pravastatin Sodium in Dosage Forms","volume":"1","author":"Bodiwala K. B.","year":"2014","journal-title":"Journal of Pharmacy and Applied Sciences|July\u2013December"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"35","article-title":"Spectroscopic and High\u2010Performance Liquid Chromatography Methods for Determination of Statins","volume":"63","author":"Bozhanov S.","year":"2016","journal-title":"Pharmacia"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-97072008000400010"},{"issue":"4","key":"e_1_2_12_18_1","first-page":"1017","article-title":"Development of Spectrophotometric Method for Determination of Pravastatin Sodium in Bulk and Tablet Formulations","volume":"1","author":"Bulk D. O. P. S. I.","year":"2009","journal-title":"Development"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826070701815288"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826070701853784"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4172\/1948-593X.1000168"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2020.113987"},{"issue":"6","key":"e_1_2_12_23_1","first-page":"485","article-title":"Differential Pulse Polarographic Determination of Pravastatin Sodium in Tablets","volume":"52","author":"Coskun N.","year":"1997","journal-title":"Pharmazie"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/892470"},{"issue":"2","key":"e_1_2_12_25_1","first-page":"160","article-title":"Simultaneous Determination of Pravastatin and Its Main Metabolite, 3\u2032\u03b1\u2010Isopravastatin in Human Plasma by HPLC\u2013MS","volume":"25","author":"Deng M.","year":"2005","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"issue":"1","key":"e_1_2_12_26_1","first-page":"197","article-title":"Development and Validation of Reverse Phase High Performance Liquid Chromatography Method for the Estimation of Pravastatin Sodium in Tablet Dosage Form","volume":"3","author":"Doshi D.","year":"2010","journal-title":"Asian Journal of Research in Chemistry"},{"issue":"3","key":"e_1_2_12_27_1","first-page":"869","article-title":"Development and Validation of UV Spectrophotometric Methods for the Estimation of Pravastatin Sodium in Bulk and Tablet Dosage Form","volume":"3","author":"Doshi D.","year":"2010","journal-title":"Research Journal of Pharmacy and Technology"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600831120"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2005.09.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-15.3.160"},{"issue":"3","key":"e_1_2_12_31_1","first-page":"143","article-title":"Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations","volume":"1","author":"El\u2010Olemy A.","year":"2017","journal-title":"Journal of Advanced Pharmacy Research"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-02746-5"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032710903060669"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039060-00002"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2478\/acph-2014-0039"},{"key":"e_1_2_12_36_1","volume-title":"StatPearls","author":"Hill M. F.","year":"2020"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2024.2305746"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199404000-00014"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100329"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.080"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.720"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.905"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040865"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0801(199809\/10)12:5<271::AID-BMC746>3.0.CO;2-F"},{"key":"e_1_2_12_45_1","volume-title":"Pravastatin'In Farmas\u00f6tik Preparatlarda Kapiler Elektroforez Ile Miktar Tayini","author":"K\u0131rcal\u0131 K.","year":"2001"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.farmac.2003.11.006"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.05.016"},{"issue":"2","key":"e_1_2_12_48_1","first-page":"123","article-title":"Determination of Pravastatin in Rat Liver by RP\u2010HPLC","volume":"36","author":"Li X.","year":"2001","journal-title":"Yao xue xue bao [Acta Pharmaceutica Sinica]"},{"issue":"6","key":"e_1_2_12_49_1","first-page":"384","article-title":"Determination of Pravastatin in Rat Plasma by Solid Phase Extraction and RP\u2010HPLC","volume":"21","author":"Li X.","year":"2001","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"issue":"3","key":"e_1_2_12_50_1","first-page":"159","article-title":"Liquid Chromatographic Determination of Dopamine, Methyldopa, l\u2010DOPA and Tyrosine in Pharmaceutical Preparations Using 2\u2010Hydroxynaphthaldehyde as a Derivatizing Reagent","volume":"4","author":"Majidano A. A.","year":"2013","journal-title":"International Journal"},{"issue":"5","key":"e_1_2_12_51_1","first-page":"164","article-title":"A Novel HPLC Method Developed and Validated for the Detection and Quantification of Atorvastatin, Fluvastatin, Pitavastatin and Pravastatin During Transdermal Delivery Studies","volume":"75","author":"Maree S.","year":"2020","journal-title":"Die Pharmazie\u2010An International Journal of Pharmaceutical Sciences"},{"issue":"2","key":"e_1_2_12_52_1","first-page":"230","article-title":"Development, Optimization and Validation of HPLC Method for Determination of Pravastatin Sodium in Tablets","volume":"3","author":"Maslarska V.","year":"2014","journal-title":"International Journal of Advances in Pharmacy, Biology and Chemistry"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.01.060"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq165"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200220102"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00372-1"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3623"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974-4150.2024.00060"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201190226"},{"issue":"5","key":"e_1_2_12_60_1","article-title":"Carbon Surfaces for the Oxidative Quantification of Pravastatin: Glassy\u2010Carbon vs. Screen\u2010Printed Carbon Electrodes","volume":"18","author":"Neves M. M.","year":"2010","journal-title":"Journal of Food and Drug Analysis"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-0188-1"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.5772\/48694"},{"key":"e_1_2_12_63_1","unstructured":"Nigovi\u0107 B. andI.Vegar.2007.Determination of Pravastatin and Separation of Its Interconversion Products in Acidic Media Using Capillary Electrophoresis. Paper Presented at the 12th International Meeting on Recent Developments in Pharmaceutical Analysis Abstract Book."},{"issue":"4","key":"e_1_2_12_64_1","first-page":"615","article-title":"Capillary Electrophoresis Determination of Pravastatin and Separation of Its Degradation Products","volume":"81","author":"Nigovi\u0107 B.","year":"2008","journal-title":"Croatica Chemica Acta"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-006-0843-5"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00625-7"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.561"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2016.10.011"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-023-03126-8"},{"issue":"64","key":"e_1_2_12_70_1","first-page":"29","article-title":"Determination of Pravastatin in Drug Formulation by Square\u2010Wave Voltammetry on a Glassy Carbon Electrode","volume":"22","author":"P\u0131nar P. T.","year":"2020","journal-title":"Dokuz Eyl\u00fcl \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi fen ve M\u00fchendislik Dergisi"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2012.01.001"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2025.124477"},{"issue":"3","key":"e_1_2_12_73_1","first-page":"13","article-title":"Novel RP\u2010HPLC Method Development and Validation for Estimation of Pravastatin in Pure and Pharmaceutical Formulation","volume":"4","author":"Prasanthi T.","year":"2021","journal-title":"Journal of Applied Pharmaceutical Sciences and Research"},{"key":"e_1_2_12_74_1","first-page":"187","article-title":"Reverse Phase HPLC Method for Determination of Pravastatin in Tablet Dosage Forms","volume":"1","author":"Raj N. D.","year":"2010","journal-title":"International Journal of Research in Pharmaceutical Sciences"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2009.10.100"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00299.x"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/22297928.2015.1062419"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974-360X.2023.00408"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v9i2.2379"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP38419"},{"issue":"9","key":"e_1_2_12_81_1","first-page":"831","article-title":"Development and Validation of a Simple and Fast HPLC Method for Determination of Lovastatin, Pravastatin and Simvastatin","volume":"50","author":"Silva T. D.","year":"2012","journal-title":"Journal of Chromatographic Science"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.08.015"},{"issue":"11","key":"e_1_2_12_83_1","first-page":"1640","article-title":"RP\u2010HPLC Determination of Related Substances of Pravastatin Sodium With Gradient Elution","volume":"26","author":"Su F.","year":"2006","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"issue":"176","key":"e_1_2_12_84_1","article-title":"An Ultra\u2010Sensitive and Selective LC\u2010UV Method for the Simultaneous Determination of Metformin, Pioglitazone, Glibenclamide and Glimepride in API, Pharmaceutical Formulations and Human Serum","volume":"5","author":"Sultana N.","year":"2013","journal-title":"Journal of Analytical & Bioanalytical Techniques"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.31.1193"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.11.007"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.5958\/2231-5659.2015.00005.3"},{"issue":"2","key":"e_1_2_12_88_1","first-page":"361","article-title":"An Improved Optimization Study for Determination of Pravastatin in Pharmaceutical Form by Using Reversed Phase Liquid Chromatography Method","volume":"7","author":"\u00dcst\u00fcn Z.","year":"2017","journal-title":"Karaelmas Science and Engineering Journal\/Karaelmas fen ve M\u00fchendislik Dergisi"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.01.038"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154685"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.12.043"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.989"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(89)80013-5"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.02.006"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3581"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0110"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00526-3"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.70335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:55:12Z","timestamp":1769831712000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/bmc.70335"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70335","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70335"}}