{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:51:47Z","timestamp":1780584707448,"version":"3.54.1"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Salvia<\/jats:italic>\n                    species are valuable natural resources due to their rich essential oils and bioactive compounds with applications in medicine, food, and cosmetics. In this study, essential oils and aroma components of\n                    <jats:italic>S. montbretii<\/jats:italic>\n                    and\n                    <jats:italic>S. hydrangea<\/jats:italic>\n                    were analyzed using GC\u2013MS\/FID and headspace GC\u2013MS. Terpenoids were identified by GC\u2013MS, while phenolic and flavonoid compounds were quantified by LC\u2013MS\/MS. Total phenolic and flavonoid contents, antioxidant capacities, and enzyme inhibitory activities were also evaluated. Caryophyllene was the dominant compound in\n                    <jats:italic>S. montbretii<\/jats:italic>\n                    essential oil and aroma samples, and camphor in\n                    <jats:italic>S. hydrangea<\/jats:italic>\n                    . GC\u2013MS results indicated high levels of ursolic (54,675.22\u20131583.23\u2009\u03bcg\/g) and oleanolic acids (100,567.85\u20132592.11\u2009\u03bcg\/g), while LC\u2013MS\/MS revealed abundant rosmarinic acid (up to 27,0857\u2013587.85\u2009\u03bcg\/g). All extracts exhibited moderate to strong antioxidant activities and notable inhibitory effects against urease and cholinesterase. Cytotoxic effects were observed on colon (Caco\u20102) and ovarian (SkOV3) cancer cell lines, along with toxicity in healthy cells (PDF). In conclusion,\n                    <jats:italic>S. montbretii<\/jats:italic>\n                    and\n                    <jats:italic>S. hydrangea<\/jats:italic>\n                    may serve as potential natural sources for pharmaceutical and cosmetic applications; however, detailed safety and dosage assessments are required prior to practical use due to the observed cytotoxic effects.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70365","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T01:24:13Z","timestamp":1769390653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GC\u2013MS and LC\u2013MS\/MS\u2013Based Phytochemical Profiling and Bioactivities of\n                    <i>Salvia montbretii<\/i>\n                    and\n                    <i>S. hydrangea<\/i>\n                    : Antioxidant, Cytotoxic and Enzyme Inhibitory Potential"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-635X","authenticated-orcid":false,"given":"Ufuk","family":"Kolak","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Cavusoglu","sequence":"additional","affiliation":[{"name":"Vocational Higher School of Health Services Mardin Artuklu University  Mardin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-4826","authenticated-orcid":false,"given":"Mehmet","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Diyarbakir Group Chairmanship The Council of Forensic Medicine  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy, Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-1710","authenticated-orcid":false,"given":"Pelin","family":"Koseoglu\u2010Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"F\u0131rat","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Education, Van Yuzuncu Yil Universiut  Van T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-8386","authenticated-orcid":false,"given":"Abdulselam","family":"Erta\u015f","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy, Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.25135\/rnp.51.17.12.080"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113566"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2023.2300737"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf048741x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.02.035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2025.2481148"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Free Radical Scavenging Activity and Total Phenol Content of Some Lamiaceae Family Species","volume":"3","author":"Babashpour\u2010Asl M.","year":"2024","journal-title":"Journal of Organic Farming of Medicinal Plants"},{"key":"e_1_2_8_9_1","first-page":"27","article-title":"Cytotoxicity, Antioxidant Activity, Total Flavonoid and Phenolic Contents of Salvia urmiensis Bunge and Salvia hydrangea DC. ex Benth","volume":"2","author":"Bahadori M. 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