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Both of them perhaps contain similar material foundations with common components, making them highly worthy of systematic analysis of the ingredients and related pharmacological mechanisms. In this study, the components in\n                    <jats:italic>BHH<\/jats:italic>\n                    were comprehensively analyzed by LC\u2013MS\/MS\u2010based molecular networking technology combined with literature reports, and important targets and core active ingredients in\n                    <jats:italic>BHH<\/jats:italic>\n                    that can treat insomnia were screened through network pharmacology and molecular docking analysis. Finally, a total of 136 components were annotated and summarized.\n                    <jats:italic>BHH<\/jats:italic>\n                    had flavonoids, fatty acids, and volatile oil as similar or the same component categories and structures as\n                    <jats:italic>Hehuanhua<\/jats:italic>\n                    , especially different categories of dihydro\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010agarofuran\u2010type sesquiterpenoids with similar functions. The screened top 10 KEGG pathways involved signal transduction related to neurotransmitters, hormones, and addictive substances, and the selected effective ingredients could play synergistic roles in inflammation regulation and neuroprotection. These results provide that\n                    <jats:italic>BHH<\/jats:italic>\n                    may be able to replace\n                    <jats:italic>Hehuanhua<\/jats:italic>\n                    in treating insomnia and other neurological disorders; modern research can provide the scientific connotation and basis for the proposed forward\u2010thinking TCM theory of \u201ceffect\u2010oriented source unification\u201d and \u201cheteroagent possessing homofunction.\u201d\n                  <\/jats:p>","DOI":"10.1002\/bmc.70370","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:50:27Z","timestamp":1769475027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Analysis Study of\n                    <scp>\n                      <i>Celastrus orbiculatus<\/i>\n                    <\/scp>\n                    Fruits (\n                    <i>Beihehuan<\/i>\n                    ) for Insomnia Treatment and Potential Replacement for\n                    <scp>\n                      <i>Albizia julibrissin<\/i>\n                    <\/scp>\n                    Flowers (\n                    <i>Hehuanhua<\/i>\n                    )"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-5005","authenticated-orcid":false,"given":"Changshui","family":"Yang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"},{"name":"The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control (Yangzhou University)  Yangzhou China"},{"name":"NATCM Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Song","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqing","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcheng","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou China"},{"name":"Testing Center Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666190617150051"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b601473a"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102021\u20100027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.13463\/j.cnki.jlzyy.1995.05.044"},{"key":"e_1_2_10_6_1","volume-title":"Norms and Standards for the Processing of Traditional Chinese Medicine Decoction Pieces of Heilongjiang Province","author":"HFDA","year":"2012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2022.10.004"},{"key":"e_1_2_10_8_1","first-page":"1859","volume-title":"Modern Compendium of Materia Medica","author":"Huang T. 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