{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:54:44Z","timestamp":1773863684494,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The aim of this study was to compare blood metabolic profiles between neonates born to propylthiouracil (PTU)\u2010treated hyperthyroid mothers and those born to healthy mothers and to evaluate potential impacts on fetal health despite maternal treatment. Blood metabolites from 31 neonates exposed to PTU and 36 healthy controls were analyzed using liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) at the Sixth Affiliated Hospital, Sun Yat\u2010sen University, and the Maternal and Child Health Care Hospital of Huadu. Metabolite differences were assessed, and enriched pathway analysis was performed to identify significantly altered metabolic pathways. Neonates exposed to PTU exhibited distinct metabolic profiles compared with controls, characterized by significantly reduced levels of histidine and aspartic acid. These differential metabolites were primarily enriched in ammonia recycling as well as glycine and serine metabolism pathways\u2014closely associated with protein and nucleotide biosynthesis. These findings indicate that prenatal exposure to PTU in hyperthyroid mothers leads to characteristic alterations in neonatal blood metabolic profiles, suggesting the need for close monitoring of growth and developmental outcomes in this population.<\/jats:p>","DOI":"10.1002\/bmc.70377","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:22:14Z","timestamp":1770358934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic Characterization of Neonates Born to Hyperthyroid Mothers"],"prefix":"10.1002","volume":"40","author":[{"given":"Jie","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Fifth Affiliated Hospital, Sun Yat\u2010sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Panyu Hospital of Traditional Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Maternal and Child Health Care Hospital of Huadu  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou 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