{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:24:27Z","timestamp":1773390267202,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005719","name":"Dicle \u00dcniversitesi","doi-asserted-by":"publisher","award":["ECZACILIK 25.003"],"award-info":[{"award-number":["ECZACILIK 25.003"]}],"id":[{"id":"10.13039\/501100005719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005719","name":"Dicle \u00dcniversitesi","doi-asserted-by":"publisher","award":["ECZACILIK 25.004"],"award-info":[{"award-number":["ECZACILIK 25.004"]}],"id":[{"id":"10.13039\/501100005719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005719","name":"Dicle \u00dcniversitesi","doi-asserted-by":"publisher","award":["FEN 25.001"],"award-info":[{"award-number":["FEN 25.001"]}],"id":[{"id":"10.13039\/501100005719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Hypericum<\/jats:italic>\n                    species have been used for medicinal purposes since ancient times because of their important pharmacological properties.\n                    <jats:italic>Hypericum triquetrifolium<\/jats:italic>\n                    Turra belongs to the Hypericaceae family and is native to Eastern Europe and the Mediterranean region. In this study, the essential oil and aroma contents of\n                    <jats:italic>H. triquetrifolium<\/jats:italic>\n                    collected from 21 different localities in the eastern region of Turkey were determined via GC\u2013MS\/FID. In addition, the antioxidant and enzyme inhibition activities (cholinesterase, tyrosinase and urease) of the essential oils and major components were determined. Finally, the essential oil and aroma contents were evaluated chemically. The major components of\n                    <jats:italic>H. triquetrifolium<\/jats:italic>\n                    collected from 21 different locations were generally determined to be octane, 2\u2010methyl (1.35%\u201325.18%),\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pinene (1.32%\u201319.1%), nonane, 3\u2010methyl (2.43%\u201324.59%) and caryophyllene (3.79%\u201330.78%). When the aroma content was examined, octane, 2\u2010methyl (14.22%\u201344%), nonane (6.37%\u201318.29%), nonane, 3\u2010methyl (7.62\u201323.12%) and decane, 2\u2010methyl (3.46%\u201322.74%) were generally identified as the major components. Overall, all samples were found to have moderate antioxidant capacity. In the AChE enzyme inhibition test, at a concentration of 100\u2009\u03bcg\/mL, samples S\u201019, S\u20109 and S\u201011 (inhibition %: 87.61\u2009\u00b1\u20090.63; 84.29\u2009\u00b1\u20091.51; 82.28\u2009\u00b1\u20090.53, respectively), and in the BChE enzyme inhibition test, the S\u20101, S\u20104 and S\u20106 samples (88.76\u2009\u00b1\u20090.79; 91.29\u2009\u00b1\u20091.58; 93.15\u2009\u00b1\u20092.16, respectively) were found to be more active than the reference galantamine. In the tyrosinase enzyme inhibition test, samples S\u20105 and S\u201013 (inhibition %: 57.09\u2009\u00b1\u20092.53 and 66.86\u2009\u00b1\u20090.50, respectively) were found to have greater activity than the other samples. A total of 21\n                    <jats:italic>H. triquetrifolium<\/jats:italic>\n                    samples collected from different regions of Diyarbak\u0131r, Mardin, Elaz\u0131\u011f, Siirt, Batman and \u015eanl\u0131urfa Provinces were analysed via principal component analysis (PCA) and cluster analysis (CA) techniques on the basis of volatile and aroma components. PCA revealed that the dominant volatile components in the samples formed three groups, and regional differences had no significant effect on the samples. The first two principal components explained 59.2% of the variance. The antioxidant capacities of essential oils, their high contents of compounds such as\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pinene and caryophyllene, and their strong acetyl and butyrylcholinesterase enzyme inhibition activities are considered to have potential for use in the food, cosmetics and pharmaceutical industries.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70391","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T13:09:22Z","timestamp":1771420162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detailed Chemical Investigation of the Essential Oil and Aroma Contents of 21\n                    <i>Hypericum triquetrifolium<\/i>\n                    Turra Species Collected From Different Localities via a Chemometric Approach"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-1515","authenticated-orcid":false,"given":"Serkan","family":"Yigitkan","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Dicle University  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-4826","authenticated-orcid":false,"given":"Mehmet","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"The Council of Forensic Medicine, Ministry of Justice  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge\u00a0Tokul","family":"Olmez","sequence":"additional","affiliation":[{"name":"Deparment of Chemistry, Faculty of Science Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mugla Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Cavusoglu","sequence":"additional","affiliation":[{"name":"Vocational Higher, School of Health Services Mardin Artuklu University  Mardin T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Dicle University  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Biology Y\u00fcz\u00fcnc\u00fc Y\u0131l University, Faculty of Education  Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Deparment of Chemistry, Faculty of Science Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mugla 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