{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:24:37Z","timestamp":1773390277445,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Paroxysmal atrial tachycardia (PAT) is a supraventricular arrhythmia associated with increased risk of atrial fibrillation (AF) and adverse cardiovascular events, but mechanisms underlying adverse outcomes remain unclear. We integrated serum metabolomics (LC\u2013MS\/MS), pathway enrichment, transcriptomic profiling, and in\u00a0vitro validation in a PAT\u2010onset cohort (five patients and five matched controls) and a PAT\u2010events cohort (10 with and 10 without adverse events). Differential metabolites and pathways were identified, and GSEA focused on ABC transporters and alanine, aspartate, and glutamate metabolism. PAT exhibited metabolic dysregulation enriched in amino\u2010acid metabolism and inflammation. Taurocholic acid was increased in PAT with adverse events and showed strong predictive value. Integrative analyses highlighted ABC transporter and alanine\/aspartate\/glutamate metabolism pathways. ABCA9 was upregulated, whereas ABCB10 and ABCC6 were downregulated in patient data and tachycardia transcriptomics, and these changes were confirmed in paced HL\u20101 atrial myocytes. ADSS1, AGXT2, and ASS1 were downregulated, indicating disrupted aspartate\u2010linked metabolism; reduced ABCB10 suggested impaired mitochondrial homeostasis. Overall, PAT is characterized by metabolic remodeling involving ABC transporter dysfunction, amino\u2010acid metabolic impairment, mitochondrial dysfunction, and vascular instability, supporting biomarker\u2010guided risk stratification and targeted intervention.<\/jats:p>","DOI":"10.1002\/bmc.70409","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:24:04Z","timestamp":1772983444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic and Genomic Insights Into Adverse Events in Paroxysmal Atrial Tachycardia"],"prefix":"10.1002","volume":"40","author":[{"given":"Qiuyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ordos Central Hospital, Ordos School of Clinical Medicine Inner Mongolia Medical University  Hohhot Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-124X","authenticated-orcid":false,"given":"Tingting","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-1108","authenticated-orcid":false,"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.025"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183167"},{"key":"e_1_2_14_4_1","first-page":"2303","article-title":"SK Channel Block and Adrenergic Stimulation Counteract Acetylcholine\u2010Induced Arrhythmogenic Effects in Human Atria","volume":"2020","author":"Celotto C.","year":"2020","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.86"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2979"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20231992"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.028"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030191"},{"key":"e_1_2_14_10_1","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-016-1030-9","article-title":"Non\u2010Targeted UHPLC\u2010MS Metabolomic Data Processing Methods: A Comparative Investigation of Normalisation, Missing Value Imputation, Transformation and Scaling","volume":"12","author":"Guida R. 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