{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:15:23Z","timestamp":1778822123350,"version":"3.51.4"},"reference-count":99,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Coccidiosis caused by\n                    <jats:italic>Eimeria<\/jats:italic>\n                    spp. is a major constraint to global poultry production, causing economic losses exceeding USD 13 billion annually. Growing drug resistance from prolonged anticoccidial use highlights the need for safer, eco\u2010friendly alternatives. Edible mushrooms, such as\n                    <jats:italic>Agaricus bisporus<\/jats:italic>\n                    , are rich in bioactive phytochemicals, yet their anticoccidial potential remains underexplored. This study investigated the methanolic extract of\n                    <jats:italic>A. bisporus<\/jats:italic>\n                    (ABE) for inhibitory effects on\n                    <jats:italic>Eimeria papillata<\/jats:italic>\n                    oocyst sporulation and interactions with essential apicomplexan enzymes. ABE was chemically characterized by GC\u2010MS, identifying 25 compounds, predominantly lipids, terpenoids, and steroids, with major constituents including 9,12\u2010octadecadienoic acid (Z,Z)\u2010 (24.65%), vitamin E (17.91%), and cis\u2010vaccenic acid (15.84%). In\u00a0vitro assays demonstrated concentration\u2010dependent inhibition of oocyst sporulation, achieving 83.44% at 72\u2009h and 87.97% at 96\u2009h (200\u2009mg\/mL), surpassing amprolium and comparable to disinfectants. Mechanistic insights via deep\u2010learning\u2013rescored molecular docking of major compounds against enoyl\u2010ACP reductase (ENR) and lactate dehydrogenase (LDH) suggested multiligand interactions, whereas ADMET predictions indicated favorable gut retention and safety profiles. These findings position ABE as a promising, eco\u2010friendly anticoccidial candidate. Future in\u00a0vivo studies are warranted to validate its efficacy and practical application in poultry production.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70450","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:37:16Z","timestamp":1777437436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Experimental and Computational Evaluation of the Gut\u2010Targeted Anticoccidial Potential of\n                    <i>Agaricus bisporus<\/i>\n                    Methanolic Extract"],"prefix":"10.1002","volume":"40","author":[{"given":"Esam\u00a0M.","family":"Al\u2010Shaebi","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":false,"given":"Mohamed\u00a0A.","family":"Dkhil","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Capital University (formerly Helwan University)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-1846","authenticated-orcid":false,"given":"Mohammed","family":"Albeshr","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8043-3098","authenticated-orcid":false,"given":"Seifeldin","family":"Elabed","sequence":"additional","affiliation":[{"name":"Biotechnology and Genetic Engineering Department, Faculty of Science Helwan National University  Helwan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simeon","family":"Santourlidis","sequence":"additional","affiliation":[{"name":"Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty Heinrich\u2010Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8185-9111","authenticated-orcid":false,"given":"Hend\u00a0M.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-6871","authenticated-orcid":false,"given":"Rewaida","family":"Abdel\u2010Gaber","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14091114"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab294"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40160-2"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"10","article-title":"Antiprotozoal Activity of Plant Extracts and Their Bioactive Compounds Against Cryptosporidium of Zoonotic Concern","volume":"45","author":"Alawfi B. 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