{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:15:05Z","timestamp":1778822105288,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The objective of this study is to investigate the mechanism of Liuwei Jinji'er Tangsan (LJT) in preventing and treating renal damage in high\u2010altitude polycythemia (HAPC). Absorbed components in rat plasma after oral LJT administration were identified by UPLC\u2010Q\u2010TOF\u2010MS. Potential targets were predicted via SEA Search Server and SwissTargetPrediction. Disease\u2010related targets were retrieved from GeneCards and OMIM. Intersecting targets were identified, and a PPI network was constructed. Gene function and pathway enrichment analyses were conducted using Metascape. Molecular docking of key components and core targets was performed with AutoDock. Fifty\u2010six prototype\u2010absorbed components were detected. Ninety\u2010eight potential \u201cLJT\u201d targets for renal protection in HAPC were identified, with core targets HIF\u20101\u03b1, MMP9, IL\u20102, ESR1, and TLR4. GO and KEGG analyses suggest LJT's \u201cblood\u2010clearing\u201d, antihypertensive, and lipid\u2010lowering effects act mainly on cell\u2010surface and macromolecular complexes, interacting with kinases, cytokine receptors, and GPCRs. Consequently, it positively regulates cell migration, inflammatory and hypoxia responses, phosphorylation, and cytokine production. \u201cLJT\u201d exerts multicomponent, multitarget, and multipathway actions to achieve blood\u2010clearing, blood\u2010pressure reduction, and lipid\u2010lowering effects.<\/jats:p>","DOI":"10.1002\/bmc.70453","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:46:22Z","timestamp":1777088782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Mechanism of Liuwei Jinji'er Tangsan in Preventing and Treating Renal Damage in High\u2010Altitude Polycythemia Based on UPLC\u2010Q\u2010TOF\u2010MS, Network Pharmacology, and Molecular Docking"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4233-7087","authenticated-orcid":false,"given":"Lihe","family":"Sheng","sequence":"first","affiliation":[{"name":"Yunnan University of Chinese Medicine  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Gao","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuhua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4408-3153","authenticated-orcid":false,"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine  Kunming Yunnan China"},{"name":"First Clinical Medical College of Yunnan University of Chinese Medicine  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010121316"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.13452\/j.cnki.jqmc.2021.03.012"},{"issue":"6","key":"e_1_2_10_4_1","first-page":"53","article-title":"Research Progress on the Preparation of Tibetan Medicinal Zomu'a Decoction Powder","author":"Basan D. 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