{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:15:41Z","timestamp":1778822141014,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aurantii Fructus<\/jats:italic>\n                    (AF), the dried immature fruit of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Citrus aurantium<\/jats:italic>\n                    <\/jats:styled-content>\n                    L., is a widely used qi\u2010regulating herb in clinical practice. Traditional medical texts describe AF as \u201cthe older, the better,\u201d implying that aging moderates its medicinal properties and enhances efficacy, although the mechanisms remain unclear. Here, dynamic changes in volatile and nonvolatile components during AF aging were investigated using long\u2010term natural aging and accelerated aging models, involving raw AF and four processed forms. Compositional variations across aging stages were characterized by high\u2010performance liquid chromatography (HPLC), electronic nose analysis, and multivariate chemometrics. During long\u2010term aging, flavonoid glycosides such as naringin gradually decreased and stabilized, whereas small\u2010molecule flavonoids and polymethoxyflavonoids increased, likely due to microbial transformation. Compared with raw AF, processed products better preserved key active constituents during aging, indicating improved quality stability. Electronic nose results showed an overall decline in volatile components, particularly hydrocarbons such as D\u2010limonene, supporting the traditional concept that aging reduces \u201cdryness.\u201d However, high\u2010temperature processing accelerated volatile loss, and accelerated aging caused more drastic compositional changes, potentially compromising quality. Overall, this study clarifies the chemical basis of the \u201cthe older, the better\u201d concept of AF and provides scientific support for quality evaluation and aging process optimization.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70462","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:19:22Z","timestamp":1776737962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Material Basis of the \u201cthe Older, the Better\u201d Phenomenon in\n                    <i>Aurantii Fructus<\/i>\n                    Using Fingerprinting Combined With Chemometric Analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"Abdulla","family":"Yusuf","sequence":"first","affiliation":[{"name":"The Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry Kashi University  Xinjiang Uygur Autonomous Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component\u2010Based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyue","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4246-7883","authenticated-orcid":false,"given":"Xiaoliang","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Fu","sequence":"additional","affiliation":[{"name":"Increasepharm (Tianjin) Institute Co. 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