{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:11:55Z","timestamp":1778821915121,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002349","name":"Academy of Scientific Research and Technology","doi-asserted-by":"publisher","award":["respect1\u201010032"],"award-info":[{"award-number":["respect1\u201010032"]}],"id":[{"id":"10.13039\/501100002349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ceiba insignis<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ceiba speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    are utilized in traditional medicine for treating inflammatory diseases. The analysis of their extracts by LC\u2010ESI\u2010MS\/MS revealed the presence of flavonoids like kaempferol hexoside and apigenin\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010deoxyhexosyl hexoside and fatty acids, namely, sterculic acid, \u03b1\u2010linolenic acid, and dihydrosterculic acid.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u2009insignis<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract decreased 5\u2010lipoxygenase and tumor necrosis factor alpha (TNF\u2010\u03b1) gene expression by 0.2908\u2010fold and 0.3276\u2010fold, whereas\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u2009speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract reduced their expression by 0.4392\u2010fold and 0.2663\u2010fold, respectively. In response to lipopolysaccharide stimulation, both extracts had anti\u2010inflammatory effects like those of the control medication celecoxib, which decreased 5\u2010LOX and TNF\u2010\u03b1 expression by 0.3554\u2010fold and 0.2263\u2010fold, respectively. Molecular docking highlighted that dihydrosterculic acid showed the tightest fit within 5\u2010LOX center revealing binding energy (\u2206G\u2009=\u2009\u221235.09\u2009kcal\/mol). Consequently, this study highlighted the relevance of the flowers of both\n                    <jats:italic>Ceiba<\/jats:italic>\n                    species in treating inflammatory disorders that in turn confirmed the traditional medicinal uses of these plants.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70480","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:11:32Z","timestamp":1778055092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Metabolic Profiling and Anti\u2010Inflammatory Evaluation of\n                    <scp>\n                      <i>Ceiba speciosa<\/i>\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>Ceiba insignis<\/i>\n                    <\/scp>\n                    Flower Extracts"],"prefix":"10.1002","volume":"40","author":[{"given":"Kholoud Kh.","family":"Kadry","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Misr International University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashaimaa Y.","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-2639","authenticated-orcid":false,"given":"Fadia S.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal S.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Misr International University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA06273A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041718"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117884"},{"key":"e_1_2_8_5_1","first-page":"666","article-title":"Taxonomy, Phytochemistry, and Therapeutic Potentials of the Genus Ceiba (Bombacaceae): A Review","volume":"5","author":"Abouelela M. 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