{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:13:47Z","timestamp":1778822027599,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis, a parasitic disease transmitted by freshwater snails, affects over 251.4 million people globally, with sub\u2010Saharan Africa bearing 95% of the disease burden. This study evaluates the phytochemical composition, characterizes the bioactive secondary metabolites, antioxidant, anti\u2010inflammatory, and the cercaricidal properties, as well as the biosafety of the methanolic and hexane extracts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Chromolaena odorata<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Phytochemical screening of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u2009odorata<\/jats:italic>\n                    <\/jats:styled-content>\n                    extracts identified tannins, flavonoids, and saponins in the methanolic extract and steroids and alkaloids in the hexane extract. LC\u2010MS and HPLC\u2010UVESI\u2010TOF\u2010MS analyses confirmed the presence of polyphenols (flavonoids) and aromatic dicarboxylic acid compounds. Antioxidant analysis revealed strong free radical scavenging potential of the plant extracts. Both extracts demonstrated potent cercaricidal activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with LC\n                    <jats:sub>50<\/jats:sub>\n                    values as low as 0.2012 and 0.2410\u2009\u03bcg\/mL, respectively. The anti\u2010inflammatory effects were determined via inhibition of heat\u2010induced albumin denaturation, with plant extracts able to inhibit protein denaturation, particularly the methanolic extract that shows a percentage of inhibition of 73.56% at the highest concentration tested. Cytotoxicity assays on LLCMK2 cells showed low toxicity of the extracts. These findings suggest that crude\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. odorata<\/jats:italic>\n                    <\/jats:styled-content>\n                    extracts possess antischistosomal, antioxidant, and anti\u2010inflammatory properties, supporting their potential integration into primary healthcare strategies for schistosomiasis control.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70484","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:27:21Z","timestamp":1778808441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of\n                    <scp>\n                      <i>Chromolaena odorata<\/i>\n                    <\/scp>\n                    Extracts Against Cercariae From\n                    <scp>\n                      <i>Schistosoma mansoni<\/i>\n                    <\/scp>\n                    : Pharmacological Related Properties and Phytochemical Profile"],"prefix":"10.1002","volume":"40","author":[{"given":"Dongmo Nguepi Mireille","family":"Sylviane","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science University of Buea  Buea Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itoe Ubre","family":"Sicca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science University of Buea  Buea Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-1335","authenticated-orcid":false,"given":"Sofeu Feugaing David","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science University of Buea  Buea Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tincho 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