{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:54:17Z","timestamp":1781765657957,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20519"],"award-info":[{"award-number":["U23A20519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070584"],"award-info":[{"award-number":["82070584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Sophora tonkinensis<\/jats:italic>\n                    , a traditional Chinese medicine with heat\u2010clearing, detoxifying, and throat\u2010soothing properties, has shown potential in treating hepatitis, inhibiting tumors, and regulating immunity, but its active constituents and mechanisms remain unclear. We established a hepatocellular carcinoma (HCC) model in SD rats using diethylnitrosamine (DEN), with oral gavage of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. tonkinensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (STE) from Weeks 1 to 16, alongside model and normal control groups. Results showed that STE significantly reduced HCC incidence, reversed weight loss, decreased the number and volume of liver nodules, improved histopathological damage, and lowered serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and albumin (ALB) levels. Integrated transcriptomic (RNA\u2010seq) and metabolomic (LC\u2013MS\/MS) analyses revealed enrichment in arachidonic acid and glycerophospholipid metabolism. Quantitative real\u2010time polymerase chain reaction (qPCR) validation confirmed that STE restored hepatic lipid homeostasis and alleviated inflammation by activating the peroxisome proliferator\u2010activated receptor (PPAR) pathway and suppressing the IL\u201017\/TGF\u2010\u03b2 axis. These findings clarify the core mechanisms of STE in preventing and treating HCC, providing a theoretical basis for its precise clinical application.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70486","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:45:16Z","timestamp":1778913916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Sophora tonkinensis<\/i>\n                    Alleviates Progression of Diethylnitrosamine\u2010Induced Hepatocellular Carcinoma in Rats via Multitarget Regulation"],"prefix":"10.1002","volume":"40","author":[{"given":"Zongliang","family":"Lu","sequence":"first","affiliation":[{"name":"School of Food Science and Biological Engineering Chengdu University  Chengdu China"},{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincai","family":"Wen","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Li","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Huang","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Wang","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Xu","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhan","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-2738","authenticated-orcid":false,"given":"Xiaohe","family":"Xiao","sequence":"additional","affiliation":[{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Science and Biological Engineering Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-150X","authenticated-orcid":false,"given":"Zhaofang","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Food Science and Biological Engineering Chengdu University  Chengdu China"},{"name":"China Military Institute of Chinese Medicine The Fifth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Hepatology The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01098-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh0831"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117406"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-025-04978-9"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"36","article-title":"Hepatocellular Carcinoma in the Cirrhotic Liver: Evaluation Using Computed Tomography and Magnetic Resonance Imaging","volume":"15","author":"Coskun M.","year":"2017","journal-title":"Experimental and Clinical Transplantation"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44057-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.09.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-025-04950-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.70093"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1630460"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.324383"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2026.02.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1374179"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np5002016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077195"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.07.025"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28166118"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/plb.13578"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2021.01083"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32283-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.91"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417686"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.039"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.052381"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113879"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157800"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.14218\/FIM.2023.00043"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.14218\/FIM.2022.00057"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.11.019"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00704-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155135"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.01.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111572"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119871"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105756"},{"issue":"4","key":"e_1_2_10_39_1","first-page":"5247","article-title":"Integration of Transcriptomics, Proteomics, Metabolomics and Systems Pharmacology Data to Reveal the Therapeutic Mechanism Underlying Chinese Herbal Bufei Yishen Formula for the Treatment of Chronic Obstructive Pulmonary Disease","volume":"17","author":"Zhao P.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/HM9.0000000000000119"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X24500794"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.70486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:22:02Z","timestamp":1781763722000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/bmc.70486"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70486","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70486"}}