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Yeasts, particularly\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , possess remarkable metabolic plasticity; thus, it paves the way for identifying antibacterial substances from their extracellular metabolome as it remains underexplored. In the present study, a semi\u2010preparative high\u2010performance liquid chromatography (HPLC) method was developed and optimized for the efficient isolation and purification of hydrocinnamic acid (3\u2010phenylpropionic acid) from the extracellular metabolite extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The purified compound was characterized using UV\u2013Vis, FTIR, NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C), GC\u2013MS, and X\u2010ray diffraction analyses. This study represents the first report of hydrocinnamic acid isolated and purified from the extracellular metabolites of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The antibacterial potential of the purified hydrocinnamic acid was assessed against multidrug\u2010resistant (MDR) strains of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Enterobacter cloacae<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , which exhibited concentration\u2010dependent inhibition against all tested pathogens, with distinct activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. cloacae<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The minimum inhibitory concentrations were 10\u2009\u03bcg\/mL for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , 15\u2009\u03bcg\/mL against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. cloacae<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and 40\u2009\u03bcg\/mL against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Collectively, these results underscore the unexplored antibacterial potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010derived extracellular metabolites and position hydrocinnamic acid as a promising natural candidate for combating multidrug\u2010resistant bacteria.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70505","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:54:27Z","timestamp":1780898067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrocinnamic Acid From\n                    <scp>\n                      <i>Candida albicans<\/i>\n                    <\/scp>\n                    : Isolation, Characterization, and Antibacterial Activity Against Multidrug\u2010Resistant Bacteria"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-7841","authenticated-orcid":false,"given":"Megharethnam","family":"Kaviraj","sequence":"first","affiliation":[{"name":"Centre for Advanced Studies in Botany University of Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-2372","authenticated-orcid":false,"given":"K. 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