{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:53:32Z","timestamp":1781765612060,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of plant compounds that may be more effective in treating infections caused by fungal pathogens. In this context, this study aimed to investigate the antifungal potential of the saponin\u2010enriched fraction of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Sarcomphalus joazeiro<\/jats:italic>\n                    <\/jats:styled-content>\n                    species against the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida tropicalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida krusei<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains. The selection of this species for study is due to its rich phytochemical composition and the vast traditional knowledge of its medicinal properties. The fraction obtained from the stem bark of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. joazeiro<\/jats:italic>\n                    <\/jats:styled-content>\n                    was analyzed by UPLC\u2010QTOF\u2010MS\/MS, in which compounds such as triterpenoids, flavonoids, acids, and saponins were identified. Therefore, the results obtained in this study contribute to understanding the antifungal potential of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. joazeiro<\/jats:italic>\n                    <\/jats:styled-content>\n                    species fraction against fungal infections, especially those caused by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida<\/jats:italic>\n                    <\/jats:styled-content>\n                    spp.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70509","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:55:58Z","timestamp":1780984558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UPLC\u2010QTOF\u2010MS\/MS and Antifungal Activity of a Fraction Enriched in Saponins From\n                    <i>Sarcomphalus joazeiro<\/i>\n                    Against\n                    <i>Candida<\/i>\n                    spp"],"prefix":"10.1002","volume":"40","author":[{"given":"Ana Raquel Pereira","family":"da Silva","sequence":"first","affiliation":[{"name":"Graduate Program in Biotechnology Universidade Estadual do Cear\u00e1 (UECE)  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"do Socorro Costa","sequence":"additional","affiliation":[{"name":"Graduate Program in Biotechnology Universidade Estadual do Cear\u00e1 (UECE)  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara Juliana Santos","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory Applied Microbiology (LAMAP) Universidade Federal do Cariri (UFCA)  Brejo Santo Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Gon\u00e7alves","family":"Alencar","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology (LMBM) Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talysson Felismino","family":"Moura","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology (LMBM) Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Juno Alencar","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-3168","authenticated-orcid":false,"given":"Ant\u00f4nia Thassya Lucas","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Flaviana Bezerra","family":"Morais\u2010Braga","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erl\u00e2nio Oliveira","family":"de Souza","sequence":"additional","affiliation":[{"name":"Faculdade de Tecnologia do Cariri (FATEC)  Juazeiro do Norte Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josean Fechine","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal da Para\u00edba (UFPB)  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Riceli Vasconcelos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Multiuser Laboratory (LMQPN) Embrapa Tropical Agroindustry  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Cosmo","family":"Andrade\u2010Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory Applied Microbiology (LAMAP) Universidade Federal do Cariri (UFCA)  Brejo Santo Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology (LMBM) Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"},{"name":"Department of Biological Chemistry Universidade Regional do Cariri (URCA)  Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2020.66.4.17"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2019.06.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.02.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.102066"},{"key":"e_1_2_9_7_1","unstructured":"Bezerra\u2010Neto F. 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