{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:55:10Z","timestamp":1781765710097,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    6\u2010Hydroxykaempferol\u20103,6\u2010diglucoside is an important flavonoid constituent of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Carthamus tinctorius<\/jats:italic>\n                    <\/jats:styled-content>\n                    L., with potential antioxidant and myocardial protective effects. However, its pharmacokinetic characteristics in normal and diabetic cardiomyopathy (DCM) mice remain unknown. This study was designed to explore the pharmacokinetic differences of this component between normal mice and DCM mice induced by a high\u2010fat diet combined with streptozotocin. All mice were intragastrically administered at a dose of 20\u2009mg\/kg. Plasma samples were collected at different time points, and the plasma concentration was determined by LC\u2013MS\/MS. Compared with normal mice, DCM mice showed significantly decreased AUC\n                    <jats:sub>\n                      0\u2212\n                      <jats:italic>t<\/jats:italic>\n                    <\/jats:sub>\n                    and\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    , indicating reduced absorption and bioavailability, while plasma clearance was markedly increased, suggesting accelerated elimination. No significant differences in\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    and\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    were observed. In contrast to our previous study, another core safflower component, HSYA, exhibited enhanced absorption and delayed elimination under DCM conditions, showing an opposite trend. These findings suggest that DCM may exert distinct regulatory effects on different bioactive ingredients of safflower, providing a comprehensive experimental basis for the clinical application of safflower\u2010containing preparations.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70521","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:02Z","timestamp":1781513822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetic Characteristics of 6\u2010Hydroxykaempferol\u20103,6\u2010Diglucoside in Normal and Diabetic Cardiomyopathy Mice"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9843-0333","authenticated-orcid":false,"given":"Rui","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pharmacy Xi'an Peoples' Hospital (Xi'an Fourth Hospital)  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxin","family":"Han","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine  Xianyang Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Xi'an Peoples' Hospital (Xi'an Fourth Hospital)  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"386","article-title":"Antidiabetic Effect of Hydroalcoholic Extract of Carthamus tinctorius L. in Alloxan\u2010Induced Diabetic Rats","volume":"17","author":"Asgary S.","year":"2012","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical 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