{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:42:27Z","timestamp":1786117347203,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) represent major global health burdens. It is urgent to develop reliable and non\u2010invasive testing technologies that can detect HCC early. The progress of urine metabolomics research has been exponential in the past decade (2016\u20132026). The method of analyzing volatile organic compounds (VOCs) provides more effective profiles than the traditional analysis of polar metabolites. As an example, in the earliest studies of gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis, researchers identified several organic acids capable of differentiating healthy subjects from individuals with HCC. Despite these advances, distinguishing between cirrhosis and HCC remains challenging, delaying patient management and complicating urgent clinical decisions. New high\u2010resolution analytical techniques such as gas chromatography\u2010time\u2010of\u2010flight mass spectrometry (GC\u2010TOF\u2010MS) and gas chromatography\u2010ion mobility spectrometry (GC\u2010IMS) make the detection of minute quantities of aromatic compounds, ketones, and aldehydes much more manageable. The TENDENCY study was designed to evaluate these technologies within a large multicenter framework; however, outcome data have not yet been published. Overall, recent evidence suggests that urine metabolomics may represent a superior approach compared to invasive methods for earlier detection of hepatic disorder because the markers enable scientists to build up a \u201cliquid biopsy\u201d model.<\/jats:p>","DOI":"10.1002\/bmc.70541","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:28:58Z","timestamp":1783567738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Gas Chromatography\u2010Based Metabolomics for Early Detection of Liver Cirrhosis and Hepatocellular Carcinoma: A Decade of Progress"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-1704","authenticated-orcid":false,"given":"Diaa I.","family":"Osman","sequence":"first","affiliation":[{"name":"National Liver Institute, Menoufia University  Shebeen El Kom Egypt"},{"name":"College of Pharmacy, Al\u2010Farahidi University  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheta M.","family":"Sheta","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0849-380X","authenticated-orcid":false,"given":"Mostafa I.","family":"Abdelglil","sequence":"additional","affiliation":[{"name":"College of Medical Laboratory Techniques, Al\u2010Farahidi University  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-5232","authenticated-orcid":false,"given":"Fatma O.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Department National Liver Institute, Menoufia University  Shebeen El Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed M.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Technology of Medical Laboratories, Faculty of Applied Health Sciences Technology Menoufia University  Shebin El\u2010Koom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser A.","family":"Naser","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Al\u2010Mustaqbal University  Hillah, Babylon Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Attia","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology Department National Liver Institute, Menoufia University  Shebeen El Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2022.107567"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12657"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13030368"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092447"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010023\u201000632\u2010z.Metabolic"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061726"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151516"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S150312"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13040\u2010017\u20100155\u20103"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010019\u201003945\u2010w"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.17998\/jlc.2022.12.30"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071085"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010023\u201003092\u20105"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1531108"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000543757"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00885"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000042"},{"issue":"1343","key":"e_1_2_13_19_1","first-page":"1","article-title":"Gas Chromatography\u2010Mass Spectrometry (GC\u2010MS) in the Plant Metabolomics Toolbox: GC\u2010MS in Multi\u2010Platform Metabolomics and Integrated Multi\u2010Omics Research","volume":"27","author":"Frolova N.","year":"2026","journal-title":"Int. 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