{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:26:38Z","timestamp":1786692398643,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH\u2010Z25294"],"award-info":[{"award-number":["LBH\u2010Z25294"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The theory of medicinal properties of traditional Chinese medicine is the core guideline for syndrome differentiation and medication.\n                    <jats:italic>Herba Siegesbeckiae<\/jats:italic>\n                    (\n                    <jats:italic>HS<\/jats:italic>\n                    ) is cold in property, and its medicinal property changes from cold to warm after processing. Based on metabolomics technology, this study investigates the regulatory effects of processed\n                    <jats:italic>HS<\/jats:italic>\n                    (\n                    <jats:italic>pro\u2010 HS<\/jats:italic>\n                    ) and its separated fractions on the neuro\u2013endocrine\u2013metabolic network in cold syndrome rats, aiming to clarify the characteristics associated with medicinal properties. Chemical separation techniques were employed to isolate the main chemical components of\n                    <jats:italic>pro\u2010HS<\/jats:italic>\n                    . A cold syndrome rat model was established via ice water stimulation. Differential expression metabolites (DEMs) and key metabolic pathways were screened by metabolomics, and combined ELISA technology to detect neuro\u2013endocrine\u2013metabolic\u2010related indicators. A total of 48 DEMs were identified, involving 11 core metabolic pathways.\n                    <jats:italic>Pro\u2010HS<\/jats:italic>\n                    and its diterpenoid fraction exerted regulatory effects on the abnormal neurotransmitters, thyroid hormones, and energy metabolism enzyme activities in cold syndrome rats. The\n                    <jats:italic>pro\u2010HS<\/jats:italic>\n                    and its separated fractions exert targeted regulatory effects on metabolic disorders in cold syndrome rats. The mechanism is closely associated with the regulation of the neuro\u2010endocrine\u2010energy metabolism network and related metabolic pathways.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70572","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:17:47Z","timestamp":1785403067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Warm Property Mechanism of\n                    <i>Pro\u2010 HS<\/i>\n                    and Its Separated Fractions Based on Metabolomics"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-4313","authenticated-orcid":false,"given":"Ajiao","family":"Hou","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Shan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejian","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixue","family":"Kuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-1107","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-3330","authenticated-orcid":false,"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin 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and Materia Medica Research"},{"issue":"17","key":"e_1_2_12_16_1","first-page":"4682","article-title":"Study on Drug Properties of Arisaematis Rhizoma and Arisaema Cum Bile Based on Substance and Energy Metabolism in Normal and Cold\/Heat Syndrome Model Rats","volume":"47","author":"Su F.","year":"2022","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-020-09714-4"},{"issue":"5","key":"e_1_2_12_18_1","first-page":"997","article-title":"Study on Material Basis of A\u00e7a\u00ed Cold Drug Based on Neuro\u2010Endocrine\u2010Immune Network","volume":"45","author":"Wang L.","year":"2020","journal-title":"China Journal of Chinese Materia 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